Table 1 Basic characteristics of included studies
Author | Year | Country | Design | Number of subjects | No. of patients with chondrosarcoma | Gender (M/F) | Age (mean, years) | Type of cartilaginous bone neoplasms | Inclusion interval | Imaging | Cutoff value of SUVmax | Injected dose | Reference test |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Annovazzi et al. [14] | 2019 | Italy | R | 95 | 60 | 40/55 | 53 ± 15 | Enchondroma and chondrosarcoma | 2011-2017 | PET and PET/CT | 2.6 | 5 MBq/kg | Post-surgical histology diagnosis, clinical and radiologic follow-up |
Purandare et al. [15] | 2019 | India | R | 66 | 40 | NR | NR | Chondrosarcoma, enchondroma, and osteochondroma | 2008.1-2018.6 | PET/CT | 3.1 | 5 MBq/kg | Post-surgical or a bioptic-histological diagnosis, clinical and radiologic follow-up |
Vadi, et al [16] | 2018 | India | R | 31 | NR | 20/21 | 42.19 (17-69) | Chondrosarcoma | 2010.1-2016.12 | PET/CT | NR | 300-370 MBq | Pooled information from histological results and clinical or imaging follow-up |
Jesus-Garcia et al. [12] | 2016 | Brazil | P | 36 | 19 | 12/24 | 44 (21-68) | Enchondroma and chondrosarcoma | 2009.10-2015.5 | PET/CT | 2.2 | 3.7 MBq/kg | Post-surgical histological diagnosis, clinical and radiologic follow-up |
Costelloe et al. [20] | 2013 | USA | R | 18 | 5 | NR | NR | Enchondroma and chondrosarcoma | 2007.1.1-2010.10.1 | PET/CT | NR | 370 MBq or 555-740 MBq | Pooled information from histological results and clinical or imaging follow-up |
Purandare et al. [21] | 2009 | India | R | 12 | 4 | 7/5 | 29.9 ± 11.6 (15-50) | Osseocartilaginous tumor, chondrosarcoma | 2005-2007 | PET/CT | 1.3/3.3 | 370 MBq | Pooled information from histological results and clinical or imaging follow-up |
Shin et al. [22] | 2008 | South Korea | R | 12 | 6 | NR | NR | Chondroblastoma, chondroma, enchondroma, and chondrosarcoma | 2004.5-2007.6 | PET/CT | 3.8 | 8.14 MBq/kg | Pooled information from histological results and clinical or imaging follow-up |
Strobel et al. [23] | 2008 | Switzerland | P | 7 | 3 | NR | NR | Chondrosarcoma, osteochondroma, chondroblastoma, and enchondroma | NR | PET | 2.5 | 350-400 MBq | Pooled information from histological results and clinical or imaging follow-up |
Feldman et al. [24] | 2005 | USA | R | 29 | 18 | 9/20 | 53 ± 17.58 (11-85) | Enchondroma, osteochondroma, and chondrosarcoma | 2000-2003 | PET | 2 | 5.18 MBq/kg | Pooled information from histological results and clinical or imaging follow-up |
Brenner et al. [25] | 2004 | USA | R | 31 | 31 | 17/14 | 50.4 ± 14.3 (23-85) | Chondrosarcoma | 1995.5-2002.5 | PET | NR | 370 MBq | Post-surgical histology diagnosis |
Lee et al. [26] | 2004 | USA | R | 27 | 13 | 18/9 | NR | Enchondroma, osteochondroma, and chondrosarcoma | 1999-2002 | PET | NR | 5.18 MBq/kg | Histopathologic examination |
Aoki et al. [27] | 1999 | Japan | P | 11 | 5 | 4/7 | 44.3 ± 21.0 (12-78) | Enchondroma, osteochondroma, and chondrosarcoma | 1997.8-1998.12 | PET | 1.3 | 5 MBq/kg | Histopathologic examination |