Table 5 Significantly down-regulated genes in both bone and kidney (GZZSZTW vs. Blank)

Tripartite motif-containing protein 59 (Trim59)

63.96

30.75

− 1.06

4.41E−47

3.76

0.91

− 2.05

2.92E−11

Collagen alpha-2(VI) chain (Col6a2)

3.99

1.59

− 1.33

5.97E−07

6.90

1.73

− 2.00

3.15E−25

Lysyl oxidase homolog 1 (Loxl1)

2.55

0.87

− 1.55

2.63E−04

6.67

3.20

− 1.06

2.23E−07

Rano class II histocompatibility antigen, B alpha chain (Rt1ba)

16.32

4.02

− 2.02

1.59E−13

83.32

40.73

− 1.03

1.32E−30

72 kDa type IV collagenase (Mmp2)

4.72

1.68

− 1.49

6.19E−08

4.49

1.63

− 1.46

1.11E−09

Collagen alpha-1(V) chain (Col5a1)

1.84

0.38

− 2.28

1.27E−09

3.71

1.35

− 1.46

3.82E−21

Olfactomedin-like protein 3 (Olfml3)

6.31

0.48

− 3.72

2.17E−15

7.82

2.56

− 1.61

1.51E−10

Mono [ADP-ribose] polymerase PARP16 (Parp16)

4.18

1.65

− 1.34

4.41E−05

16.13

6.90

− 1.23

1.45E−20

Hemoglobin subunit beta-1 (Hbb1)

318449.91

105658.11

− 1.59

0

1173.62

298.69

− 1.97

0

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl)

1.55

0.06

− 4.69

2.94E−08

12.17

1.14

− 3.42

2.01E−60

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (Apobec3a)

0.76

0.17

− 2.16

1.95E−04

2.11

1.00

− 1.08

4.95E−06

Hemoglobin subunit beta-2 (Hbb2)

25744.68

10685.16

− 1.27

0

107.40

24.59

− 2.13

2.24E−56

Galectin-5 (Lgals5)

619.97

306.05

− 1.02

2.49E−117

5.43

1.47

− 1.89

8.97E−05

Mitochondrial fission regulator 1 (Mtfr1)

9.27

2.99

− 1.63

4.01E−06

22.05

10.25

− 1.11

1.90E−09

Solute carrier organic anion transporter family member 2B1 (Slco2b1)

3.18

1.00

− 1.67

6.28E−08

3.65

1.07

− 1.77

3.73E−13

Macrophage-expressed gene 1 protein (Mpeg1)

22.34

9.15

− 1.29

1.29E−32

4.09

1.94

− 1.08

5.11E−08

Insulin-like growth factor-binding protein 4 (Igfbp4)

22.16

10.42

− 1.09

7.73E−15

80.24

20.72

− 1.95

6.94E−157

Decorin (Dcn)

56.87

19.21

− 1.57

2.30E−45

87.18

20.12

− 2.12

4.97E−145

Calcipressin-1 (Rcan1)

6.83

3.03

− 1.17

5.07E−06

46.91

23.12

− 1.02

1.38E−33

Phosphoserine aminotransferase (Psat1)

6.86

2.84

− 1.27

2.21E−06

191.68

64.45

− 1.57

9.36E−259

Selenoprotein P (Sepp1)

118.47

23.76

− 2.32

1.56E−194

1943.71

875.64

− 1.15

0

Coronin-1C (Coro1c)

4.42

0.61

− 2.86

1.71E−07

13.29

5.98

− 1.15

1.06E−08

Collagen alpha-1(I) chain (Col1a1)

198.95

66.96

− 1.57

0

7.51

1.09

− 2.78

1.51E−64

DNA damage-inducible transcript 4 protein (Ddit4)

7.25

2.05

− 1.82

7.97E−09

43.56

21.42

− 1.02

3.31E−26

Endoglin (Eng)

3.61

0.85

− 2.09

6.83E−09

36.46

17.26

− 1.08

4.64E−41

Monocarboxylate transporter 1 (Slc16a1)

40.94

18.51

− 1.15

2.32E−32

56.75

5.62

− 3.34

1.52E−236

Slit homolog 3 protein (Slit3)

1.32

0.28

− 2.24

8.69E−07

2.19

1.02

− 1.10

6.17E−06

Hephaestin (Heph)

2.31

0.85

− 1.44

1.15E−05

3.50

1.56

− 1.17

8.10E−09

Caspase-4 (Casp4)

6.86

2.71

− 1.34

9.64E−05

5.85

2.47

− 1.24

9.73E−05

Carboxypeptidase Q (Cpq)

7.40

1.89

− 1.97

1.29E−09

136.94

65.28

− 1.07

3.24E−93

Aurora kinase B (Aurkb)

14.57

6.47

− 1.17

1.52E−09

0.77

0.01

− 6.27

2.34E−04

Complement C1q tumor necrosis factor-related protein 6 (C1qtnf6)

2.76

0.50

− 2.46

5.54E−07

1.31

0.29

− 2.18

1.81E−04

Glia-derived nexin (Serpine2)

85.20

34.85

− 1.29

1.67E−60

8.47

1.53

− 2.47

1.82E−22

A disintegrin and metalloproteinase with thrombospondin motifs 2 (Adamts2)

1.28

0.27

− 2.25

5.20E−08

1.02

0.26

− 1.97

3.48E−05

Glutathione peroxidase 3 (Gpx3)

186.91

71.69

− 1.38

5.73E−109

12320.88

4891.04

− 1.33

0

Arachidonate 15-lipoxygenase (Alox15)

34.62

13.20

− 1.39

2.33E−32

1.61

0.10

− 4.01

6.27E−08

Insulin-like growth factor-binding protein 3 (Igfbp3)

5.44

2.70

− 1.01

1.45E−04

64.08

16.86

− 1.93

9.00E−137

Collagen alpha-1(III) (Col3a1)

18.19

4.02

− 2.18

3.35E−68

17.97

2.29

− 2.97

6.13E−133

Osteomodulin (Omd)

7.34

0.75

− 3.29

1.52E−16

3.64

1.41

− 1.37

9.08E−05