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Table 5 Significantly down-regulated genes in both bone and kidney (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene nameBoneKidney
Blank (FPKM)GZZSZTW (FPKM)log2 fold change (GZZSZTW/Blank)p valueBlank (FPKM)GZZSZTW (FPKM)log2 fold change (GZZSZTW/Blank)p value
Tripartite motif-containing protein 59 (Trim59)63.9630.75− 1.064.41E−473.760.91− 2.052.92E−11
Collagen alpha-2(VI) chain (Col6a2)3.991.59− 1.335.97E−076.901.73− 2.003.15E−25
Lysyl oxidase homolog 1 (Loxl1)2.550.87− 1.552.63E−046.673.20− 1.062.23E−07
Rano class II histocompatibility antigen, B alpha chain (Rt1ba)16.324.02− 2.021.59E−1383.3240.73− 1.031.32E−30
72 kDa type IV collagenase (Mmp2)4.721.68− 1.496.19E−084.491.63− 1.461.11E−09
Collagen alpha-1(V) chain (Col5a1)1.840.38− 2.281.27E−093.711.35− 1.463.82E−21
Olfactomedin-like protein 3 (Olfml3)6.310.48− 3.722.17E−157.822.56− 1.611.51E−10
Mono [ADP-ribose] polymerase PARP16 (Parp16)4.181.65− 1.344.41E−0516.136.90− 1.231.45E−20
Hemoglobin subunit beta-1 (Hbb1)318449.91105658.11− 1.5901173.62298.69− 1.970
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl)1.550.06− 4.692.94E−0812.171.14− 3.422.01E−60
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (Apobec3a)0.760.17− 2.161.95E−042.111.00− 1.084.95E−06
Hemoglobin subunit beta-2 (Hbb2)25744.6810685.16− 1.270107.4024.59− 2.132.24E−56
Galectin-5 (Lgals5)619.97306.05− 1.022.49E−1175.431.47− 1.898.97E−05
Mitochondrial fission regulator 1 (Mtfr1)9.272.99− 1.634.01E−0622.0510.25− 1.111.90E−09
Solute carrier organic anion transporter family member 2B1 (Slco2b1)3.181.00− 1.676.28E−083.651.07− 1.773.73E−13
Macrophage-expressed gene 1 protein (Mpeg1)22.349.15− 1.291.29E−324.091.94− 1.085.11E−08
Insulin-like growth factor-binding protein 4 (Igfbp4)22.1610.42− 1.097.73E−1580.2420.72− 1.956.94E−157
Decorin (Dcn)56.8719.21− 1.572.30E−4587.1820.12− 2.124.97E−145
Calcipressin-1 (Rcan1)6.833.03− 1.175.07E−0646.9123.12− 1.021.38E−33
Phosphoserine aminotransferase (Psat1)6.862.84− 1.272.21E−06191.6864.45− 1.579.36E−259
Selenoprotein P (Sepp1)118.4723.76− 2.321.56E−1941943.71875.64− 1.150
Coronin-1C (Coro1c)4.420.61− 2.861.71E−0713.295.98− 1.151.06E−08
Collagen alpha-1(I) chain (Col1a1)198.9566.96− 1.5707.511.09− 2.781.51E−64
DNA damage-inducible transcript 4 protein (Ddit4)7.252.05− 1.827.97E−0943.5621.42− 1.023.31E−26
Endoglin (Eng)3.610.85− 2.096.83E−0936.4617.26− 1.084.64E−41
Monocarboxylate transporter 1 (Slc16a1)40.9418.51− 1.152.32E−3256.755.62− 3.341.52E−236
Slit homolog 3 protein (Slit3)1.320.28− 2.248.69E−072.191.02− 1.106.17E−06
Hephaestin (Heph)2.310.85− 1.441.15E−053.501.56− 1.178.10E−09
Caspase-4 (Casp4)6.862.71− 1.349.64E−055.852.47− 1.249.73E−05
Carboxypeptidase Q (Cpq)7.401.89− 1.971.29E−09136.9465.28− 1.073.24E−93
Aurora kinase B (Aurkb)14.576.47− 1.171.52E−090.770.01− 6.272.34E−04
Complement C1q tumor necrosis factor-related protein 6 (C1qtnf6)2.760.50− 2.465.54E−071.310.29− 2.181.81E−04
Glia-derived nexin (Serpine2)85.2034.85− 1.291.67E−608.471.53− 2.471.82E−22
A disintegrin and metalloproteinase with thrombospondin motifs 2 (Adamts2)1.280.27− 2.255.20E−081.020.26− 1.973.48E−05
Glutathione peroxidase 3 (Gpx3)186.9171.69− 1.385.73E−10912320.884891.04− 1.330
Arachidonate 15-lipoxygenase (Alox15)34.6213.20− 1.392.33E−321.610.10− 4.016.27E−08
Insulin-like growth factor-binding protein 3 (Igfbp3)5.442.70− 1.011.45E−0464.0816.86− 1.939.00E−137
Collagen alpha-1(III) (Col3a1)18.194.02− 2.183.35E−6817.972.29− 2.976.13E−133
Osteomodulin (Omd)7.340.75− 3.291.52E−163.641.41− 1.379.08E−05