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Table 2 The expression levels of kidney markers and regulators involved in kidney function, regulation, and repair (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene name

Blank (FPKM)

GZZSZTW (FPKM)

log2 fold change (GZZSZTW/Blank)

p value

Kidney markers

 Uromodulin (Umod)

1882.20

3124.23

0.73

0

 Solute carrier family 7 member 13 (Slc7a13)

947.10

1462.48

0.63

0

 Solute carrier family 12 member 1 (Slc12a1)

344.12

554.10

0.69

0

 Aquaporin-2 (Aqp2)

325.29

485.70

0.58

7.21E−88

 *Solute carrier family 22 member 12 (Slc22a12)

122.60

279.04

1.19

2.06E−266

 Transmembrane protein 52B (Tmem52b)

138.18

239.13

0.79

1.26E−107

 Solute carrier family 12 member 3 (Slc12a3)

121.71

192.57

0.66

6.73E−128

 Transmembrane protein 174 (Tmem174)

124.35

143.94

0.21

1.05E−05

 N-acetyltransferase 8 (Nat8)

114.50

115.27

0.01

5.98E−01

 FXYD domain-containing ion transport regulator 4 (Fxyd4)

83.00

114.50

0.46

1.31E−08

 Aquaporin-6 (Aqp6)

45.56

88.40

0.96

3.48E−36

 *Solute carrier family 22 member 13 (Slc22a13)

29.45

62.88

1.09

2.27E−79

 Transmembrane protein 72 (Tmem72)

41.21

55.59

0.43

1.39E−25

 Podocin (Nphs2)

43.01

52.46

0.29

1.37E−04

 Pendrin (Slc26a4)

26.32

51.83

0.98

1.20E−49

 Nephrin (Nphs1)

18.71

32.02

0.78

1.87E−43

 Chloride channel protein ClC-Ka (Clcnka)

19.56

31.06

0.67

1.00E−14

 Paired box protein Pax-2 (Pax2)

17.22

19.31

0.17

3.71E−02

 Single-minded homolog 1 (Sim1)

9.44

11.14

0.24

6.44E−02

 Transient receptor potential cation channel subfamily V member 5 (Trpv5)

2.62

4.00

0.61

2.98E−04

 Uroplakin-1a (Upk1a)

2.26

3.75

0.73

3.43E−02

 *Sclerostin (Sost)

0.01

3.06

8.26

3.22E−05

Kidney regulator

 *Protein S100-A6 (S100a6)

85.59

204.01

1.25

3.25E−29

 *Clusterin (Clu)

38.41

87.28

1.18

1.38E−66

 *Vimentin (Vim)

29.83

67.37

1.18

4.97E−53

 *Solute carrier family 22 member 13 (Slc22a13)

29.45

62.88

1.09

2.27E−79

 *Dexamethasone-induced Ras-related protein 1 (Rasd1)

3.14

6.68

1.09

2.22E−05

 Annexin A1 (Anxa1)

66.96

105.55

0.66

3.53E−25

 Neutrophil gelatinase-associated lipocalin (Lcn2)

6.19

10.56

0.77

3.93E−03

 Actin-related protein 2/3 complex subunit 1B (Arpc1b)

61.49

74.90

0.28

1.22E−05

 Cyclic AMP-dependent transcription factor ATF-3 (Atf3)

1.51

1.72

0.19

6.07E−01

 Claudin-4 (Cldn4)

20.40

32.96

0.69

3.13E−12

 Metalloproteinase inhibitor 1 (Timp1)

3.05

5.24

0.78

7.42E−02

 Annexin A2 (Anxa2)

62.35

71.45

0.20

3.37E−03

 Signal transducer CD24 (Cd24)

154.61

215.25

0.48

8.30E−39

 Prominin-1 (Prom1)

12.64

18.60

0.56

1.18E−10

 Arginase-1 (Arg1)

0.93

1.98

1.09

3.03E−02

 Protein Wnt-7b (Wnt7b)

7.57

10.73

0.50

1.36E−02

 Macrophage colony-stimulating factor 1 (Csf1)

4.12

6.26

0.60

2.88E−01

 Fibrinogen beta chain (Fgb)

5.70

6.81

0.26

2.38E−01

 Fibrinogen alpha chain (Fga)

13.81

14.93

0.11

3.63E−01

  1. *significantly upregulated genes under GZZSZTW treatment