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Table 2 The expression levels of kidney markers and regulators involved in kidney function, regulation, and repair (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene nameBlank (FPKM)GZZSZTW (FPKM)log2 fold change (GZZSZTW/Blank)p value
Kidney markers
 Uromodulin (Umod)1882.203124.230.730
 Solute carrier family 7 member 13 (Slc7a13)947.101462.480.630
 Solute carrier family 12 member 1 (Slc12a1)344.12554.100.690
 Aquaporin-2 (Aqp2)325.29485.700.587.21E−88
 *Solute carrier family 22 member 12 (Slc22a12)122.60279.041.192.06E−266
 Transmembrane protein 52B (Tmem52b)138.18239.130.791.26E−107
 Solute carrier family 12 member 3 (Slc12a3)121.71192.570.666.73E−128
 Transmembrane protein 174 (Tmem174)124.35143.940.211.05E−05
 N-acetyltransferase 8 (Nat8)114.50115.270.015.98E−01
 FXYD domain-containing ion transport regulator 4 (Fxyd4)83.00114.500.461.31E−08
 Aquaporin-6 (Aqp6)45.5688.400.963.48E−36
 *Solute carrier family 22 member 13 (Slc22a13)29.4562.881.092.27E−79
 Transmembrane protein 72 (Tmem72)41.2155.590.431.39E−25
 Podocin (Nphs2)43.0152.460.291.37E−04
 Pendrin (Slc26a4)26.3251.830.981.20E−49
 Nephrin (Nphs1)18.7132.020.781.87E−43
 Chloride channel protein ClC-Ka (Clcnka)19.5631.060.671.00E−14
 Paired box protein Pax-2 (Pax2)17.2219.310.173.71E−02
 Single-minded homolog 1 (Sim1)9.4411.140.246.44E−02
 Transient receptor potential cation channel subfamily V member 5 (Trpv5)2.624.000.612.98E−04
 Uroplakin-1a (Upk1a)2.263.750.733.43E−02
 *Sclerostin (Sost)0.013.068.263.22E−05
Kidney regulator
 *Protein S100-A6 (S100a6)85.59204.011.253.25E−29
 *Clusterin (Clu)38.4187.281.181.38E−66
 *Vimentin (Vim)29.8367.371.184.97E−53
 *Solute carrier family 22 member 13 (Slc22a13)29.4562.881.092.27E−79
 *Dexamethasone-induced Ras-related protein 1 (Rasd1)3.146.681.092.22E−05
 Annexin A1 (Anxa1)66.96105.550.663.53E−25
 Neutrophil gelatinase-associated lipocalin (Lcn2)6.1910.560.773.93E−03
 Actin-related protein 2/3 complex subunit 1B (Arpc1b)61.4974.900.281.22E−05
 Cyclic AMP-dependent transcription factor ATF-3 (Atf3)1.511.720.196.07E−01
 Claudin-4 (Cldn4)20.4032.960.693.13E−12
 Metalloproteinase inhibitor 1 (Timp1)3.055.240.787.42E−02
 Annexin A2 (Anxa2)62.3571.450.203.37E−03
 Signal transducer CD24 (Cd24)154.61215.250.488.30E−39
 Prominin-1 (Prom1)12.6418.600.561.18E−10
 Arginase-1 (Arg1)0.931.981.093.03E−02
 Protein Wnt-7b (Wnt7b)7.5710.730.501.36E−02
 Macrophage colony-stimulating factor 1 (Csf1)4.126.260.602.88E−01
 Fibrinogen beta chain (Fgb)5.706.810.262.38E−01
 Fibrinogen alpha chain (Fga)13.8114.930.113.63E−01
  1. *significantly upregulated genes under GZZSZTW treatment