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Table 1 The expression levels of bone cell markers (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene name

Blank (FPKM)

GZZSZTW (FPKM)

log2 fold change (GZZSZTW/Blank)

p value

Osteoblast markers

Collagen alpha-1(I) chain (Col1a1)

198.95

66.96

− 1.57

0

Alkaline phosphatase, (Alpl)

15.81

5.33

− 1.57

6.62E−20

Bone sialoprotein 2 (Ibsp)

91.97

17.38

− 2.40

2.20E−150

Osteocalcin (Bglap)

872.04

147.20

− 2.57

6.10E−313

Osteopontin (Spp1)

96.37

34.42

− 1.49

5.87E−64

Osteomodulin (Omd)

7.34

0.75

− 3.29

1.52E−16

Decorin (Dcn)

56.87

19.21

− 1.57

2.30E−45

Osteoclast markers

Tartrate-resistant acid phosphatase type 5 (Acp5)

103.22

13.98

− 2.88

6.00E−147

Cathepsin K (Ctsk)

82.80

6.46

− 3.68

3.00E−150

Nuclear factor of activated T-cells, cytoplasmic 3 (Nfatc3)

6.77

3.28

− 1.05

5.21E−12

Myc proto-oncogene protein (Myc)

14.37

6.47

− 1.15

1.13E−11

Osteocyte markers

Podoplanin (Pdpn)

3.33

1.10

− 1.60

8.21E−04

Dentin matrix acidic phosphoprotein 1 (Dmp1)

45.75

5.78

− 2.98

7.15E−132

Sclerostin (Sost)

11.75

0.57

− 4.37

2.85E−11

Metalloendopeptidase homolog PEX (Phex)

0.82

0.12

− 2.77

9.62E−05

Matrix extracellular phosphoglycoprotein (Mepe)

40.91

4.96

− 3.04

2.53E−73

Dickkopf-related protein 1 (Dkk1)

3.65

0.37

− 3.30

3.92E−11