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Table 1 The expression levels of bone cell markers (GZZSZTW vs. Blank)

From: Deciphering the potential pharmaceutical mechanism of Guzhi Zengsheng Zhitongwan on rat bone and kidney based on the “kidney governing bone” theory

Gene nameBlank (FPKM)GZZSZTW (FPKM)log2 fold change (GZZSZTW/Blank)p value
Osteoblast markers
Collagen alpha-1(I) chain (Col1a1)198.9566.96− 1.570
Alkaline phosphatase, (Alpl)15.815.33− 1.576.62E−20
Bone sialoprotein 2 (Ibsp)91.9717.38− 2.402.20E−150
Osteocalcin (Bglap)872.04147.20− 2.576.10E−313
Osteopontin (Spp1)96.3734.42− 1.495.87E−64
Osteomodulin (Omd)7.340.75− 3.291.52E−16
Decorin (Dcn)56.8719.21− 1.572.30E−45
Osteoclast markers
Tartrate-resistant acid phosphatase type 5 (Acp5)103.2213.98− 2.886.00E−147
Cathepsin K (Ctsk)82.806.46− 3.683.00E−150
Nuclear factor of activated T-cells, cytoplasmic 3 (Nfatc3)6.773.28− 1.055.21E−12
Myc proto-oncogene protein (Myc)14.376.47− 1.151.13E−11
Osteocyte markers
Podoplanin (Pdpn)3.331.10− 1.608.21E−04
Dentin matrix acidic phosphoprotein 1 (Dmp1)45.755.78− 2.987.15E−132
Sclerostin (Sost)11.750.57− 4.372.85E−11
Metalloendopeptidase homolog PEX (Phex)0.820.12− 2.779.62E−05
Matrix extracellular phosphoglycoprotein (Mepe)40.914.96− 3.042.53E−73
Dickkopf-related protein 1 (Dkk1)3.650.37− 3.303.92E−11