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Table 3 Outcomes of meta-analysis in early surgery for hip fracture patients with or without antiplatelet therapy and subgroup analysis based on different drug regimens

From: Is hip fracture surgery safe for patients on antiplatelet drugs and is it necessary to delay surgery? A systematic review and meta-analysis

OutcomesNo. of trialsNo. of participantsWMD or OR (95% CI)Subtotal p valueSubtotal Heterogenicity (I2 = %)p value between subgroup (I2 = %)p value
AntiplateletControl
In-hospital mortality
 Aspirin311/45624/11281.11 (0.54-2.32)0.7700.810.59
 Clopidogrel42/10626/12421.17 (0.34-3.99)0.800
 Clopidogrel and aspirin11/348/6192.31 (0.28-19.05)0.44Not applicable
30-day mortality
 Aspirin225/37142/7561.22 (0.72-2.07)0.47890.640.56
 Clopidogrel58/182121/20701.20 (0.55-2.60)0.650
 Clopidogrel and aspirin11/3439/6190.45 (0.06-3.38)0.44Not applicable
1-year mortality
 Aspirin285/371131/7561.91 (0.56-6.54)0.30900.550.43
 Clopidogrel329/110488/15340.90 (0.49-1.64)0.7241
 Clopidogrel and aspirin17/34117/6191.11 (0.47-2.62)0.81Not applicable
Drop in hemoglobin
 Aspirin44508790.12 (− 0.06-0.31)0.1800.880.08
 Clopidogrel620110170.16 (− 0.10-0.42)0.220
 Clopidogrel and aspirin1346190.00 (− 0.58-0.58)1.00Not applicable
Number of patients receiving blood transfusion
 Aspirin4253/450465/8791.16 (0.91-1.46)0.2300.390.03
 Clopidogrel10118/361875/29651.19 (0.90-1.59)0.2336
 Clopidogrel and aspirin124/34337/6192.01 (0.94-4.27)0.07Not applicable
Mean number of units of blood transfused
 Aspirin553011850.13 (− 0.13-0.40)0.32490.230.07
 Clopidogrel725024870.15 (− 0.25-0.56)0.4671
 Clopidogrel and aspirin2496410.69 (0.10-1.28)0.020
Length of hospital stay
 Aspirin2380808− 0.39 (− 0.83-0.06)0.0900.030.76
 Clopidogrel625712030.58 (− 0.17-1.34)0.130
 Clopidogrel and aspirin2496410.97 (− 0.40-2.34)0.170
Reoperation
 Aspirin23/2233/3041.35 (0.28-6.61)0.7100.930.29
 Clopidogrel610/21633/10371.47 (0.70-3.09)0.310
Acute coronary syndrome
 Aspirin18/1185/1371.92 (0.61-6.04)0.26Not applicable0.520.004
 Clopidogrel614/24019/9842.27 (1.07-4.81)0.030
 Clopidogrel and aspirin13/150/2212.60 (0.60-264.14)0.10Not applicable
Cerebrovascular events
 Aspirin22/1401/1591.64 (0.27-9.79)0.59390.760.53
 Clopidogrel32/844/2491.77 (0.35-9.04)0.490
 Clopidogrel and aspirin10/151/220.46 (0.02-12.12)0.64Not applicable
Deep venous thrombosis
 Aspirin39/47611/9231.50 (0.58-3.84)0.40610.940.30
 Clopidogrel42/16214/14351.60 (0.45-5.74)0.470
 Clopidogrel and aspirin10/349/6190.93 (0.05-16.33)0.96Not applicable
Pulmonary embolism
 Aspirin22/3584/7861.06 (0.22-5.14)0.9500.790.54
 Clopidogrel62/25114/16641.37 (0.44-4.23)0.590
 Clopidogrel and aspirin10/342/6193.58 (0.17-76.02)0.41Not applicable
Wound-related complications
 Aspirin414/49825/9450.86 (0.44-1.69)0.6700.340.48
 Clopidogrel814/28735/23981.52 (0.75-3.09)0.240
 Clopidogrel and aspirin22/4910/6412.60 (0.49-13.74)0.260
Major bleeding
 Aspirin13/9810/3421.05 (0.28-3.89)0.94Not applicable0.580.48
 Clopidogrel35/9113/4441.75 (0.52-5.91)0.370