Table 3 Univariate and multivariate Cox regression analysis for overall survival(OS) in Ewing tumor patients

Variables

HR (95% CI)

p value

HR (95% CI)

p value

 ≤ 10

Reference

< 0.001***

Reference

< 0.001***

 11–20

1.873 (1.388–2.528)

< 0.001***

1.549(1.144–2.099)

0.005**

 21–30

2.351 (1.674–3.301)

< 0.001***

1.808(1.278–2.556)

0.001**

 31–49

3.494 (2.410–5.064)

< 0.001***

3.481(2.379–5.094)

< 0.001***

 ≥ 50

4.557 (2.831–7.336)

< 0.001***

4.307 (2.648–7.006)

< 0.001***

 Male

Reference

 Female

0.905 (0.746–1.099)

0.313

 White

Reference

0.008**

Reference

0.011*

 Black

2.120 (1.321–3.403)

0.002**

2.104 (1.296–3.416)

0.003**

 Other

1.025 (0.715–1.469)

0.894

1.107 (0.706–1.465)

0.928

 Limb

Reference

< 0.001***

Reference

0.004**

 Cranial

1.139 (0.730–1.778)

0.566

1.480 (0.922–2.377)

0.104

 Spine

1.478 (1.034–2.111)

0.032*

1.458 (0.999–2.129)

0.051

 Thoracic

1.062 (0.796–1.418)

0.681

0.909 (0.675–1.226)

0.532

 Pelvic

1.855 (1.493–2.305)

< 0.001***

1.462 (1.151–1.858)

0.002**

 < 5

Reference

< 0.001***

Reference

< 0.001***

 5–8

1.395 (1.025–1.898)

0.034*

1.386 (1.005–1.911)

0.046*

 > 8

1.985 (1.493–2.640)

< 0.001***

1.877 (1.376–2.561)

< 0.001***

 Localized

Reference

< 0.001***

Reference

< 0.001***

 Regional

1.512(1.148–1.991)

0.003*

1.373 (1.033–1.823)

0.029*

 Metastatic

3.820(2.897–5.038)

< 0.001***

3.259 (2.425–4.379)

< 0.001***

 No

Reference

Reference

 Yes

0.571 (0.473–0.690)

< 0.001***

0.933 (0.749–1.172)

0.536

 No

Reference

Reference

 Yes

1.352 (1.122–1.630)

0.002**

1.065 (0.874–1.299)

0.531

 No

Reference

Reference

 Yes

0.426 (0.282–0.642)

< 0.001***

0.466 (0.290–0.685)

< 0.001***