Gene polymorphisms and expression levels of interleukin-6 and interleukin-10 in lumbar disc disease: a meta-analysis and immunohistochemical study

Table 2 Distribution of genotypes and alleles of IL-6 and IL-10 gene polymorphisms in LDD patients and controls

Study			Case group					Control group					HWE for control
Author	Year	Ethnicity	11	12	22	1	2	11	12	22	1	2	HWE for control
rs1800795 (G vs. C)
Noponen-Hietala [10]	2005	European	47	77	31	171	139	37	89	53	163	195	0.97
Eskola [11]	2010	European	19	33	14	71	61	37	79	38	153	155	0.74
Kelempisioti [13]	2011	European	35	77	38	147	153	39	117	90	196	296	0.92
Huang [14]	2017	Asian	264	3	0	531	3	297	3	0	597	3	0.93
rs1800796 (C vs. G)
Noponen-Hietala [10]	2005	European	0	5	150	5	305	0	15	164	16	342	0.55
Eskola [11]	2010	European	1	10	55	12	120	1	12	141	14	294	0.20
Kelempisioti [13]	2011	European	0	9	141	9	291	0	15	231	15	477	0.62
Huang [14]	2017	Asian	138	113	16	389	145	193	102	5	488	112	0.03
Zhu [15]	2017	Asian	55	233	210	653	343	239	181	43	659	267	0.30
rs1800797 (G vs. A)
Noponen-Hietala [10]	2005	European	48	76	31	172	138	37	89	53	163	195	0.97
Eskola [11]	2010	European	17	34	15	68	64	37	79	38	153	155	0.74
Kelempisioti [13]	2011	European	34	79	37	147	153	43	116	87	201	291	0.68
rs13306435 (A vs. T)
Noponen-Hietala [10]	2005	European	0	16	139	16	294	0	4	175	4	354	0.87
Eskola [11]	2010	European	0	1	65	1	131	0	4	150	4	304	0.87
rs2069849 (T vs. C)
Noponen-Hietala [10]	2005	European	0	8	147	8	302	1	17	161	19	339	0.46
Eskola [11]	2010	European	0	3	63	3	129	0	11	143	11	297	0.64
rs1800871 (A vs. C)
Lin [13]	2011	Asian	150	113	57	413	227	89	119	61	297	241	0.08
Huang [14]	2017	Asian	91	143	33	325	209	119	153	28	391	209	0.03
rs1800896 (G vs. A)
Noponen-Hietala [10]	2005	European	32	76	47	140	170	34	88	57	156	202	0.99
Lin [13]	2011	Asian	118	113	89	349	291	122	93	54	337	201	< 0.01
Huang [14]	2017	Asian	0	70	197	70	464	0	35	265	35	565	0.28

11, 12, and 22 indicate GG GC CC for rs1800795, CC CG GG for rs1800796, GG GA AA for rs1800797, AA AT TT for rs13306435, TT TC CC for rs209849, AA AC CC for rs1800871, and GG GA AA for rs1800896 respectively

ISSN: 1749-799X