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Fig. 8 | Journal of Orthopaedic Surgery and Research

Fig. 8

From: Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway

Fig. 8

Responses of chondrocytes to stimulation by PRP-As and PRP-Exos via Wnt/β-catenin signal pathway. The chondrocytes were induced by IL-1β (10 ng/mL) stimulated and protein expression levels of β-catenin, RUNX2 and Wnt5a were estimated by Western blotting (a). Quantitative data are presented as means ± standard deviations of three independent experiments. β-actin was used as an internal control. Protein expression levels of β-catenin (b), RUNX2 (c), and Wnt5a (d) was upregulated in osteoarthritis chondrocytes, compared with control group (#P < 0.05), depressed by PRP-As and PRP-Exos(*P < 0.05). The depressed effect of PRP-Exos was more obvious than PRP-As; however, protein expression levels of β-catenin was opposite ($P < 0.05)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X