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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway

Fig. 5

Apoptosis of chondrocytes: In vitro, the apoptosis of the chondrocytes induced by IL-1β (10 ng/mL) with or without PRP-Exos, PRP-As were assessed through Annexin V-PE-H staining with flow cytometric analysis (a). In vitro, IL-1β significantly increased apoptotic rate of chondrocytes (&P < 0.05, compared with control group). PRP-Exos and PRP-As both inhibited apoptosis of chondrocytes (*P < 0.05, compared with IL-1Β group), but the effect of PRP-Exos significantly was better than PRP-As, #P < 0.05.And the low concentration of PRP-Exos and PRP-Ase either obviously inhibited apoptosis of chondrocytes (b)

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