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Table 1 The information of included studies

From: Comparison of efficacy and safety between oral and intravenous administration of tranexamic acid for primary total knee/hip replacement: a meta-analysis of randomized controlled trial

StudyCountryHip/kneeOralIVTXA administrationTXA costOutcomes
Yuan 2017 [15]ChinaK140140O: 20 mg/kg*2 dose
IV: 20 mg/kg*2 dose
O: $274.81
IV: $860.28
IVT, DVT, DHB, transfusion rate
Luo 2018 [16]ChinaH6060O: 2 g*1 dose
IV: 20 mg/kg*1 dose
O: $68.11
IV: $472.44
TBL, DHB, transfusion rate
Wang 2018 [17]ChinaK6060O: 2 g*1 dose
IV: 20 mg/kg*1 dose
O: $68.11
IV: $474.1
TBL, DHB, DVT, transfusion rate
Fillingham 2016 [18]USAK3437O: 1950 mg*1 dose
IV: 1 g*1 dose
NRTBL, DHB, HS, transfusion rate
Wu 2018 [19]ChinaH5050O: 1 g*1 dose
IV: 1 g*3 dose
O: $85.14
IV: $447
TBL, DHB, IVT, HS, transfusion rate
Cao-K 2018 [20]ChinaK5959O: 500 mg*4 dose
IV: 20 mg/kg*1dose and 1 g*3 dose
NRTBL, DVT, HS
Zhao 2018 [21]ChinaH4040O: 20 mg/kg*2 dose
IV: 15 mg/kg*2 dose
O: $77.48
IV: $648.96
TBL, DHB, IVT, transfusion rate
Kayupov 2017 [22]USAH4043O: 1950 mg*1 dose
IV: 1 g*1 dose
NRTBL, DHB, HS, transfusion rate
Cao-H 2018 [23]ChinaH5454O: 500 mg*4 dose
IV: 20 mg/kg*1 dose
NRIVT, DVT
Zohar-L 2004 [24]IsraelK2020O: 1 g*3 dose
IV: 15 mg/kg*1 dose and 10 mg/kg*1 dose
NRHS, transfusion rate
Zohar-S 2004 [24]IsraelK2020O: 1 g*3 dose
IV: 15 mg/kg*1 dose and 10 mg/kg*1 dose
NRHS, transfusion rate
  1. DVT deep vein thrombosis, IVT intramuscular venous thrombosis, DHB decline of hemoglobin, TBL total blood loss, HS length of hospital stay