Table 1 The information of included studies
Study | Country | Hip/knee | Oral | IV | TXA administration | TXA cost | Outcomes |
|---|---|---|---|---|---|---|---|
Yuan 2017 [15] | China | K | 140 | 140 | O: 20 mg/kg*2 dose IV: 20 mg/kg*2 dose | O: $274.81 IV: $860.28 | IVT, DVT, DHB, transfusion rate |
Luo 2018 [16] | China | H | 60 | 60 | O: 2 g*1 dose IV: 20 mg/kg*1 dose | O: $68.11 IV: $472.44 | TBL, DHB, transfusion rate |
Wang 2018 [17] | China | K | 60 | 60 | O: 2 g*1 dose IV: 20 mg/kg*1 dose | O: $68.11 IV: $474.1 | TBL, DHB, DVT, transfusion rate |
Fillingham 2016 [18] | USA | K | 34 | 37 | O: 1950 mg*1 dose IV: 1 g*1 dose | NR | TBL, DHB, HS, transfusion rate |
Wu 2018 [19] | China | H | 50 | 50 | O: 1 g*1 dose IV: 1 g*3 dose | O: $85.14 IV: $447 | TBL, DHB, IVT, HS, transfusion rate |
Cao-K 2018 [20] | China | K | 59 | 59 | O: 500 mg*4 dose IV: 20 mg/kg*1dose and 1 g*3 dose | NR | TBL, DVT, HS |
Zhao 2018 [21] | China | H | 40 | 40 | O: 20 mg/kg*2 dose IV: 15 mg/kg*2 dose | O: $77.48 IV: $648.96 | TBL, DHB, IVT, transfusion rate |
Kayupov 2017 [22] | USA | H | 40 | 43 | O: 1950 mg*1 dose IV: 1 g*1 dose | NR | TBL, DHB, HS, transfusion rate |
Cao-H 2018 [23] | China | H | 54 | 54 | O: 500 mg*4 dose IV: 20 mg/kg*1 dose | NR | IVT, DVT |
Zohar-L 2004 [24] | Israel | K | 20 | 20 | O: 1 g*3 dose IV: 15 mg/kg*1 dose and 10 mg/kg*1 dose | NR | HS, transfusion rate |
Zohar-S 2004 [24] | Israel | K | 20 | 20 | O: 1 g*3 dose IV: 15 mg/kg*1 dose and 10 mg/kg*1 dose | NR | HS, transfusion rate |