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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Virulence of methicillin-resistant Staphylococcus aureus modulated by the YycFG two-component pathway in a rat model of osteomyelitis

Fig. 3

ASyycG suppressed the pathogenicity of MRSA in vivo. a The normal condition showed a clearly defined cortex without apparent signs of osteolysis (upper lane); the osteomyelitis caused by S. aureus and the infected regions are indicated (red circle). b Average BV/TV values in control, ASyycG and MRSA groups (*p < 0.05, n = 10). c RT-qPCR for quantifying the expression of inflammatory mediators (*p < 0.05, n = 10). d Analysis of bone specimens using SEM identified that the spatial organization of microorganisms; The visualized microbial aggregates (red arrows) along the bone samples were generally detected in the peri-drilled sites (blue arrows) surrounding the bone surfaces

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