Fig. 4

Knockdown of p38 suppressed the activation of p38/ERK/JNK signal pathway in TGF-β1-induced BMSCs. Western blot showed that the expression of p-p38, p-ERK, and p-JNK was remarkably increased in the BMSCs under TGF-β1 induced for 14 days, while shRNA-p38 and SB203580 suppressed the activation of p38/ERK/JNK signal pathway in TGF-β1-induced BMSCs. The non-phosphorylated proteins of p38, ERK, and JNK were essentially unchanged in different groups. **p < 0.01 and ***p < 0.001 vs. control; ^##p < 0.01 and ^###p < 0.001 vs. TGF-β1