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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Artesunate prevents knee intraarticular adhesion via PRKR-like ER kinase (PERK) signal pathway

Fig. 3

ART caused fibroblast apoptosis. a Dose-dependent effects of ART on fibroblasts after an overnight treatment with different concentrations of ART. b Time-dependent effects of 10 μM ART on fibroblasts following treatment for various durations; viability was determined by the CCK-8 assay. c, d The ART-treated cells were stained with Tunnel. e, f The apoptotic cells were stained with Annexin V/PI dual-staining after treatment with 10 μM ART. g, h The Western blot revealed that ART induces the expression of cleaved-PARP. i, j The Western blot revealed that the cytoprotective effect of caspase inhibitors. GAPDH was included as a control. *P < 0.05 versus control group

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