Fig. 4

LcRNA TUG1 regulates proliferation and apoptosis of mice osteoclasts. Over-expression of lncRNA TUG1 significantly promoted the proliferation (a) and inhibited the apoptosis (b) of mice osteoclasts, while lncRNA TUG1 siRNA silencing played an opposite role. Moreover, lncRNA TUG1 over-expression led to downregulated PTEN mRNA, while lncRNA TUG1 siRNA silencing played an opposite role (c), (*p < 0.05)