The diagnostic value of soluble urokinase-type plasminogen activator receptor (suPAR) for the discrimination of vertebral osteomyelitis and degenerative diseases of the spine

Table 5 Diagnostic value of serum levels of suPAR and CRP for distinguishing between vertebral osteomyelitis and degenerative diseases of the spine

Parameter	Interval	AUC	95% confidence interval	Cut-off	Sensitivity	Specificity	Odds ratio	Positive predictive value	Negative predictive value	Youden’s index
suPAR (ng/mL)	Pre-OP	0.88	0.76–1.00	2.960	0.688	1.000	-*	1.000	0.800	0.688
suPAR (ng/mL)	Overall post-OP	0.84	0.71–0.97	4.021	0.750	0.800	12.00	0.750	0.800	0.550
CRP (mg/L)	Pre-OP	0.93	0.85–1.00	11.580	0.875	0.900	63.00	0.875	0.900	0.775
CRP (mg/L)	Overall post-OP	0.77	0.62–0.93	63.210	0.938	0.600	22.50	0.652	0.923	0.538

suPAR soluble urokinase-type plasminogen activator receptor, CRP C-reactive protein, pre-OP before surgery, post-OP after surgery, AUC the area under the receiver operating characteristics curve adjusted for sex
*No value due to a 0 in the denominator
The optimal cut-off values were determined using ROC curve analysis and Youden’s index

ISSN: 1749-799X