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Table 4 Diagnostic values of other serum or synovial fluid biomarkers for PJI

From: Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

Biomarker

Sensitivity (95% CI)

Specificity (95% CI)

Erythrocyte sedimentation rate (ESR)

86% (82.5–89%)

72.3% (70.4–74.2%)

Serum C-reactive protein (CRP)

86.9% (83.5–89.9%)

78.6% (86.9–80.3%)

Synovial fluid procalcitonin (PCT)

53% (24–80%)

92% (45–99%)

Synovial fluid CRP

92% (86–96%)

90% (87–93%)

Synovial fluid interleukin-6 (IL-6)

72% (63–80%)

91% (82–96%)