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Table 3 Pooled diagnostic parameters of ELISA and lateral flow test strip for α-defensin

From: Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

 ELISALateral flow test strip
Number of studies412
Sensitivity (95% CI)92% (86–96%)85% (80–89%)
Specificity (95% CI)99% (98–100%)96% (94–97%)
Positive likelihood ratio (95% CI)91.18 (29.53–281.49)14.91 (8.51–26.15)
Negative likelihood ratio (95% CI)0.10 (0.06–0.18)0.19 (0.11–0.34)
Diagnostic odds ratio (95% CI)1095.49 (283.68–4230.45)97.55 (46.69–203.83)
AUC0.99900.9590