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Table 2 Characteristics of 13 studies applying leukocyte esterase (LE) strip for meta-analysis

From: Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis

Study, yearCountryParticipants (M/F)Median age (range, years)Standard referenceStudy designAssay platformCutoff value
Parvizi et al. 2011&USAUA (108)UAOwn institute#PChemstrip 7 urine test strip (Roche Diagnostics, Indianapolis, Indiana)++ (+)*
Tischler et al. 2014USA90/9963 (22–90)MSISPUA++ (+)*
Deirmengian et al. 2014ζUSA28/1863/67MSISRChemstrip 7 urine test strip (Roche Diagnostics, Indianapolis, IN)++/+
Guenther et al. 2014&GermanyUA (353)67 (56–78)MSISPRoche Diagnostics GmbH, Mannheim, Germany++/+
Colvin et al. 2015&USA27/3069.1 (31–91)AAOSPChemstrip 7 urine test strips (Roche Diagnostics, Indianapolis, IN)++
Tischler et al. 2016USA30/3164.1 (45–80)MSISPUA++
De Vecchi et al. 2016ItalyUA (129)64 (17–88)MSISPDirui Industrial Co Ltd., China++/+
Ruangsomboon et al. 2017Thailand11/3569 (61–77)ICM criteriaRChemstrip 10 urine test strip; Roche Diagnostics, Indianapolis, Indiana++
Koh et al. 2017Korea13/4771 (50–85)MSISPAUTION ELEVEN, ARKRAY, Kyoto, Japan; Clinitek 500, Siemens, Munich, Germany; and Urisys 2400, Roche Diagnostics, Mannheim, Germany++
Li et al. 2017China27/3657.2 (22–80)MSISPComber 10 Test M Roche (Germany)++
Wang et al. 2017ChinaUA63 (51–75)MSISRCombur10 TestM Roche, Germany; AUTION Sticks, Arkray, Kyoto, Japan++
Li et al. 2018China81/11762 (48–76)MSISPAUTION Sticks, Arkray, Kyoto, Japan++/+
  1. UA unavailable, P prospective study, R retrospective study, ELISA enzyme-linked immunosorbent assay, ICM International Consensus Meeting
  2. *Both ++ and ++/+ as cutoff value were analyzed for the sensitivity, specificity, positive predictive value, and negative predictive value
  3. #Similar to MSIS
  4. &Blood samples excluded
  5. ζBoth bloody and non-bloody samples were analyzed for the sensitivity, specificity, positive predictive value, and negative predictive value, but only non-bloody samples were included in the meta-analysis