Fig. 5
Effect of cadherin-11 antibody on synovitis score and expression of Cadherin-11 in CIOA mice. a Representative photomicrographs of HE staining and Cadherin-11 immunostaining of synovium in CIOA mice with or without cadherin-11 antibody. Cadherin-11 antibody has significant inhibitory effect on Krenn synovitis score (e, p < 0.05), including synovial hyperplasia (b, p < 0.05), inflammatory infiltration (c, p < 0.05), and density of synovial stromal cells (d, p < 0.05). Cadherin-11 antibody significantly decreased expression of Caherin-11 in the synovial lining layer (f, p < 0.001), but not in the sublining layer (g, p > 0.05) in CIOA mice. Anti-Cad-11 represents anti-Cadherin-11 antibody therapy group (n = 6, 9, and 9 per group respectively; data presented as mean ± SEM; Kruskal–Wallis test followed by Mann–Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.001)