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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis

Fig. 3

Effect of LY294002 on synovitis score and expression of Cadherin-11 in CIOA mice. Representative photomicrographs of HE staining and Cadherin-11 immunostaining of synovium in CIOA mice with or without PI3K inhibitor, LY294002. a PI3K inhibitor, LY294002, significantly decreased expression of Caherin-11 in synovial lining layer (f, p < 0.01) and sublining layer (g, p < 0.05) of CIOA mice; however, it has no obvious effect on synovial hyperplasia, inflammatory infiltration, and density of synovial stromal cells (b, c, d, p < 0.05) as well as the total synovitis score (e, p > 0.05) (n = 6 per group respectively; data presented as mean ± SEM; Kruskal–Wallis test followed by Mann–Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.001)

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