Table 3 Urine levels of CTX-II, C2C, PYD, and Helix-II by sex among the external controls, internal controls, and KBD patients

CTX-II (ng/mmol.cre)

EC

29.19

25.17, 40.77

30

25.57, 35.00

− 0.102

0.918

IC

30.28

24.75, 37.02

26.65

22.80, 32.34

− 1.663

0.096

KBD

39.71

30.34, 62.45

45.68

29.02, 57.94

− 0.04

0.968

C2C (ng/mmol.cre)

EC

1.49

1.16, 1.73

1.51

1.27, 1.89

1.051

0.293

IC

1.67

1.27, 2.17

1.67

1.25, 1.99

− 0.718

0.473

KBD

1.99

1.35, 3.53

2.06

1.47, 3.08

0.283

0.777

PYD (nmol/mmol.cre)

EC

21.23

16.76, 28.50

23.39

18.93, 29.09

1.079

0.28

IC

24.98

21.39, 30.72

24.93

19.72, 29.23

− 0.455

0.649

KBD

30.44

20.77, 51.37

32.07

20.62, 46.49

0.364

0.716

Helix-II (nmol/mmol.cre)

EC

0.35

0.22, 0.45

0.33

0.28, 0.45

0.884

0.377

IC

0.37

0.27, 0.48

0.35

0.27, 0.53

0.42

0.674

KBD

0.45

0.31, 0.70

0.46

0.32, 0.80

0.299

0.765