Fig. 3

Levels of uCTX-II (a), uC2C (b), uPYD (c), and uHelix-II (d) in different KBD grades. The levels of the four markers in the grade I KBD group were significantly higher than those in the grade 0 KBD group (H = − 5.673, P < 0.001; H = − 3.419, P = 0.002; H = − 2.594, P = 0.028; and H = − 2.572, P = 0.030, respectively). The levels of uCTX-II (a), uC2C (b), and uPYD (c) in the grade II KBD group were significantly higher than those in the grade 0 KBD group (H = − 4.521, P < 0.001; H = − 3.228, P = 0.004; and H = − 3.148, P = 0.005, respectively). Although there were no statistically significant differences in the levels of uHelix-II (d) between the grade II KBD group and the grade 0 KBD group (H = − 2.344, P = 0.057, P value close to the significance level of 0.05), the uHelix-II level of the grade II KBD was significantly higher than that of the grade I KBD as seen in subpanel D. There were no statistically significant differences in the levels of the four markers between the grade II KBD group and the grade I KBD group (H = − 1.644, P = 0.301; H = − 1.491, P = 0.408; H = − 1.826, P = 0.204; and H = − 1.038, P = 0.898, respectively)