Table 2 Genotype association between SNPs in ASPN gene and knee osteoarthritis
From: Identifying the role of ASPN and COMP genes in knee osteoarthritis development
Genotype | All subjects | Women | Men | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Control (%) | Case (%) | OR (95% CI), p value | Control (%), 276 | Case (%), 295 | OR (95% CI), p value | Control (%), 224 | Case (%), 205 | OR (95% CI), p value | ||
Genotype | 3739606 | |||||||||
GG | 261 (52.2) | 238 (47.6) | 1.00 (ref) | 139 (50.36) | 139 (47.79) | 1.00 (ref) | 122 (54.46) | 99 (48.29) | 1.00 (ref) | |
GT | 209 (41.8) | 217 (43.4) | 1.13 (0.87–1.47), 0.325 | 119 (43.11) | 129 (43.72) | 1.06 (0.75–1.50), 0.703 | 90 (40.17) | 88 (42.92) | 1.20 (0.81–1.79), 0.355 | |
TT | 30 (6.0) | 45 (09.0) | 1.64 (1.00–2.69), 0.046* | 18 (6.52) | 27 (8.47) | 1.36 (0.71–2.62), 0.341 | 12 (5.35) | 18 (8.78) | 1.84 (0.85–4.02), 0.117 | |
Allele | G | 731 (73.1) | 693 (69.3) | 1.00 (ref) | 397 (71.92) | 411 (69.66) | 1.00 (ref) | 334 (74.53) | 286 (69.75) | 1.00 (ref) |
T | 269 (26.9) | 307 (30.7) | 1.20 (0.99–1.46), 0.060 | 155 (28.07) | 179 (30.33) | 1.11 (0.86–1.44), 0.401 | 114 (25.44) | 124 (30.24) | 1.27 (0.94–1.71), 0.116 | |
Genotype | Rs 331377 | |||||||||
AA | 201 (40.2) | 183 (36.6) | 1.00 (ref) | 114 (41.30) | 111 (37.62) | 1.00 (ref) | 87 (38.83) | 72 (35.12) | 1.00 (ref) | |
AG | 154 (30.8) | 166 (33.2) | 1.18,(0.88–1.59), 0.264 | 86 (31.15) | 96 (32.54) | 1.14 (0.77–1.69), 0.493 | 68 (30.35) | 70 (34.14) | 1.24 (0.78–1.96), 0.349 | |
GG | 145 (29.0) | 151 (30.2) | 1.14 (0.84–1.54), 0.385 | 76 (27.53) | 88 (29.83) | 1.18 (0.80–1.78), 0.368 | 69 (30.80) | 63 (30.73) | 1.10 (0.69–1.75), 0.677 | |
Allele | A | 556 (55.6) | 532 (53.2) | 1.00 (ref) | 314 (56.88) | 318 (53.89) | 1.00 (ref) | 242 (54.01) | 214 (52.19) | 1.00 (ref) |
G | 444 (44.4) | 468 (46.8) | 1.10 (0.92–1.31), 0.281 | 238 (43.11) | 272 (46.10) | 1.12 (0.89–1.42), 0.310 | 206 (45.98) | 196 (47.80) | 1.07 (0.82–1.40), 0.593 | |