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Table 1 Results by study [3,4,5,6,7,8,9,10,11,12,13,14,15]

From: A systematic review of the single-stage treatment of chronic osteomyelitis

Article

Total patients

M to F

Age (mean)

F/U month range (mean)

COM patients

Treatment method

Non- recurrence (%)

MCMS

Yamashita et al., Japan, 1998 [3]

18

10:8

16–77 (39)

24–75 (55)

14

Debridement + antibiotic loaded calcium-hydroxyapatite

100

72

Simpson et al., Oxford, 2001 [4]

15

39:11

16–78 (47.2)

12–48 (26)

8

Debridement: wide excision + gentamicin beads ± free flap

100

75

 

29

/

16–79 (42.9)

12–48 (26)

21

Debridement: marginal excision + gentamicin beads ± free flap

71.4

/

 

6

/

42–82 (67)

12–48 (26)

4

Minimal debridement

0

/

Kuokkanen et al., Helsinki, 2002 [5]

21

18:3

30–69 (34)

12–78 (36)

13

Debridement ± muscle flap

92.3

65

Hashmi et al., Sheffield, 2004 [6]

17

17:0

17–53 (37)

60–84 (70)

8

Debridement + Lautenbach

75

77

Beals et al., Oregon, 2005 [7]

30

25:5

16–80 (43.6)

24–180 (72)

7

Debridement ± muscle flap

100

60

Lu et al., China, 2006 [8]

35

28:7

16–72 (30.2)

13–55 (27.8)

26

Debridement + allograft bone grafting

92.3

63

Smith et al., Leeds, 2006 [9]

41

26:15

16–76 (45.3)

12 (12)

41

Debridement + free or local muscle flaps

95

59

Chang et al., Bologna, 2007 [10]

40

36:29

18–69 (39.8)

36–334 (75)

40

Debridement alone

60

62

 

25

/

18–69 (39.8)

36–334 (75)

25

Debridement + Osteoset-T pellets

80

/

Caesar et al., Oswestry, 2009 [11]

35

26:9

19–81 (42)

24–150 (110)

23

Debridement + Lautenbach

85.3

69

Drago et al., Milan, 2013 [12]

27

18:9

20–80 (44)

12–36 (16)

24

Debridement + bioactive glass

87.5

74

Romano et al., Milan, 2014 [13]

27 (as Milan 2013)

18:9

20–80 (44)

12–36 (21.8)

24 (as Milan 2013)

Debridement + bioactive glass

87.5

71

 

27

16:11

24–74 (47)

12–36 (22.1)

25

Debridement + antibiotic loaded calcium-hydroxyapatite

89.8

/

 

22

14:8

23–77 (44.9)

12–36 (21.5)

20

Debridement + tricalcium-phosphate with antibiotic loaded bone matrix

88.9

/

Ferguson et al., Oxford, 2014 [14]

193

150:43

16–82 (46.1)

16–85 (44)

128

Debridement + Osteoset-T ± muscle flaps

86.4

83

McNally et al., Oxford, 2016 [15]

100

65:35

23–88 (51.6)

12–34 (19.5)

78

Debridement + CERAMENT G

97.4

79