From: A systematic review of the single-stage treatment of chronic osteomyelitis
Article | Total patients | M to F | Age (mean) | F/U month range (mean) | COM patients | Treatment method | Non- recurrence (%) | MCMS |
---|---|---|---|---|---|---|---|---|
Yamashita et al., Japan, 1998 [3] | 18 | 10:8 | 16–77 (39) | 24–75 (55) | 14 | Debridement + antibiotic loaded calcium-hydroxyapatite | 100 | 72 |
Simpson et al., Oxford, 2001 [4] | 15 | 39:11 | 16–78 (47.2) | 12–48 (26) | 8 | Debridement: wide excision + gentamicin beads ± free flap | 100 | 75 |
29 | / | 16–79 (42.9) | 12–48 (26) | 21 | Debridement: marginal excision + gentamicin beads ± free flap | 71.4 | / | |
6 | / | 42–82 (67) | 12–48 (26) | 4 | Minimal debridement | 0 | / | |
Kuokkanen et al., Helsinki, 2002 [5] | 21 | 18:3 | 30–69 (34) | 12–78 (36) | 13 | Debridement ± muscle flap | 92.3 | 65 |
Hashmi et al., Sheffield, 2004 [6] | 17 | 17:0 | 17–53 (37) | 60–84 (70) | 8 | Debridement + Lautenbach | 75 | 77 |
Beals et al., Oregon, 2005 [7] | 30 | 25:5 | 16–80 (43.6) | 24–180 (72) | 7 | Debridement ± muscle flap | 100 | 60 |
Lu et al., China, 2006 [8] | 35 | 28:7 | 16–72 (30.2) | 13–55 (27.8) | 26 | Debridement + allograft bone grafting | 92.3 | 63 |
Smith et al., Leeds, 2006 [9] | 41 | 26:15 | 16–76 (45.3) | 12 (12) | 41 | Debridement + free or local muscle flaps | 95 | 59 |
Chang et al., Bologna, 2007 [10] | 40 | 36:29 | 18–69 (39.8) | 36–334 (75) | 40 | Debridement alone | 60 | 62 |
25 | / | 18–69 (39.8) | 36–334 (75) | 25 | Debridement + Osteoset-T pellets | 80 | / | |
Caesar et al., Oswestry, 2009 [11] | 35 | 26:9 | 19–81 (42) | 24–150 (110) | 23 | Debridement + Lautenbach | 85.3 | 69 |
Drago et al., Milan, 2013 [12] | 27 | 18:9 | 20–80 (44) | 12–36 (16) | 24 | Debridement + bioactive glass | 87.5 | 74 |
Romano et al., Milan, 2014 [13] | 27 (as Milan 2013) | 18:9 | 20–80 (44) | 12–36 (21.8) | 24 (as Milan 2013) | Debridement + bioactive glass | 87.5 | 71 |
27 | 16:11 | 24–74 (47) | 12–36 (22.1) | 25 | Debridement + antibiotic loaded calcium-hydroxyapatite | 89.8 | / | |
22 | 14:8 | 23–77 (44.9) | 12–36 (21.5) | 20 | Debridement + tricalcium-phosphate with antibiotic loaded bone matrix | 88.9 | / | |
Ferguson et al., Oxford, 2014 [14] | 193 | 150:43 | 16–82 (46.1) | 16–85 (44) | 128 | Debridement + Osteoset-T ± muscle flaps | 86.4 | 83 |
McNally et al., Oxford, 2016 [15] | 100 | 65:35 | 23–88 (51.6) | 12–34 (19.5) | 78 | Debridement + CERAMENT G | 97.4 | 79 |