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Table 1 List of potential outcomes

From: How to evaluate the clinical outcome of joint-preserving treatment for osteonecrosis of the femoral head: development of a core outcome set

Categories

Outcomes

Common signs and symptoms

Harris Hip Score (HHS)

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Visual analogue scale (VAS)

Charnley score

Merle D’Aubigne score

Japanese Orthopedic Association Score (JOA)

Method used to determine the percentage of adult ONFH

Syndrome integral to TCM

Clinical effective rate

ROM of flexion

Walking distance

Degree of claudication

Quality of life

MOS Short-Form Health Survey (SF-36)

12-item Short-Form Health Survey (SF-12)

Quality of Life Brief Scale (QOL-BREF)

EORTC-30 Scale

Barthel index

Long-term outcomes

Femoral head survival time

Hip joint arthroplasty rate

Femoral head collapse rate

Femoral head survival rate

Radiological evaluation

Degree of X-ray change

Degree of computed tomography (CT) change

Degree of bone marrow edema

Percentage of empty lacunae

Sample line of magnetic resonance imaging (MRI)

Necrotic bone resorption rate

New bone repair rate

Bone mineral density

Blood biochemistry

Erythrocyte sedimentation rate (ESR)

Lipid indexes

Bone Gla protein (BGP)

Endothelin (ET)

Bone morphogenetic protein 2 (BMP2)

Osteoblasts (OB)

Osteoclasts (OC)

Osteoprotegerin (OPG)

Alkaline phosphatase (ALP)

C-reactive protein (CRP)

Indexes of safety

Adverse effect rate

Adverse events

Detection of blood biochemical indexes