From: Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration
Groups | Score | Histological features |
---|---|---|
Blank group | 4 | The intervertebral disc is composed of AF arranged regularly around the periphery and the NP cells uniformly in the center. AF are arranged in half-ring-shaped structure. NP cells are distributed evenly. and the number of cells is large. |
Model group | 12 | There are fissures in the AF of the intervertebral disc, irregular arrangement. Nearly no boundary between the AF and the NP. and the NP cells almost disappear. replaced by AF tissue. showing fibrosis. |
sIL-13Rα2-Fc low-dose group | 7 | The AF was repaired aud arranged neatly. NP cells gradually increased, and distribution gradually became uniform. |
sIL-13Rα2-Fc middle-dose group | 6 | The number of NP cells is large. distribution is uniform, local disorder. AF arrangement is regular. and degree of degeneration continues to decrease. |
sIL-13Rα2-Fc high-dose group | 5 | The NP cells are evenly distributed, increase in number. more uniformly arranged . And repair marks are visible in the AF ring, which are mostly coutinuous, the arrangement is regular, and degree of degeneration is severely reduced. |