Table 3 Mean total score of injured intervertebral discs after 4 weeks of sIL-13Rα2-Fc intervention
From: Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration
Groups | Score | Histological features |
|---|---|---|
Blank group | 4 | The intervertebral disc is composed of AF arranged regularly around the periphery and the NP cells uniformly in the center.AF are arranged in half -ring -shaped structure .NP cells are distributed evenly ,and the number of cells is large. |
Model group | 12 | The arrangement of intervertebral disc AF is more disordered and twisted. The NP cells are drastically reduced and unevenly arranged. The boundary between the AF and NP cells tends to be blurred and cracks appear. |
sIL-13Rα2-Fc low-dose group | 8 | The AF ring of the intervertebral disc showed repair marks, and the arrangement of the AF tended to be neat, the number of NP cells was still small and unevenly distributed. |
sIL-13Rα2-Fc middle-dose group | 7 | AF rings were arranged neatly, and degree of degeneration was gradually reduced. The NP cells increased, and the arrangment of parts AF were still disordered. |
sIL-13Rα2-Fc high-dose group | 6 | Most of the AF rings are continuous and arrangement is very regular. The number of NP cells is large and evenly distributed. The boundaries of the AF and NP are clear, and the degree of degeneration is mostly reduced. |