Table 2 Mean total score of injured intervertebral discs after 2 weeks of sIL-13Rα2-Fc intervention
From: Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration
Groups | Score | Histological features |
|---|---|---|
Blank group | 4 | The intervertebral disc is composed of AF arranged regularly around the periphery and the NP cells uniformly in the center. AF are arranged in half-ring-shaped structure. NP cells are distributed evenly, and the number of cells is larger. |
Model group | 11 | There are fissures in the AF of the intervertebral disc, irregular arrangement. NP arrangement is obviously disordered, only part of the NP tissue is sparse ,and the number of NP cells is obviously reduced . |
sIL-13Rα2-Fc low-dose group | 9 | The NP cells are irregular, the number of NP cells is less and the distribution of NP cells is more dispersed. |
sIL-13Rα2-Fc middle-dose group | 8 | The boundary between the NP and the AF is clear,the number of NP cells begins to increase, and proteoglycan matrix begins to increase. |
sIL-13Rα2-Fc high-dose group | 7 | The NP cells are further increased, cell distribution tends to be uniform, and arrangement of the AF tends to be neat. |