Table 1 Characteristics of the 19 studies in meta-analysis for the diagnosis of PJI using α-defensin
Study | Country | Patients number | Mean age (years) | Study design | Excluded antibiotic therapy | Site of arthroplasty | Reference standard | QUADAS |
|---|---|---|---|---|---|---|---|---|
Laboratory-based immunoassay | ||||||||
Deirmengian et al., 2014 [10] | USA | 95 | 67 | Prospective | N | Hip, knee | MSIS (2011) | 14 |
Bingham et al., 2014 [9] | USA | 57 | 64.2 | Retrospective | NA | Hip, knee | MSIS (2011) | 13 |
Deirmengian et al., 2014 [10] | USA | 149 | 65 | Prospective | N | Hip, knee | MSIS (2011) | 13 |
Deirmengian et al., 2014 [10] | USA | 46 | 65 | Prospective | N | Hip, knee | MSIS (2011) | 13 |
Frangiamore et al., 2016 [15] | USA | 78 | 63.3 | Prospective | NA | Hip, knee | MSIS (2011) | 14 |
Bonanzinga et al., 2017 [19] | Germany | 156 | NA | Prospective | N | Hip, knee | MSIS (2013) | 14 |
Gehrke et al., 2018 [23] | Germany | 173 | NA | Prospective | Y | Hip, knee | MSIS (2013) | 14 |
Kanwar et al., 2018 [24] | USA | 70 | 66 | Retrospective | NA | Hip, knee | MSIS (2013) | 14 |
Sigmund et al., 2018 [42] | Germany | 71 | 70 | Retrospective | Y | Hip, knee | MSIS (2013) | 13 |
Stone et al., 2018 [43] | USA | 183 | 65.7 | Retrospective | Y | Hip, knee | MSIS (2011) | 14 |
Kelly et al., 2018 [39] | USA | 32 | 64 | Retrospective | N | Hip, knee | MSIS (2013) | 13 |
Lateral flow test | ||||||||
Kasparek et al., 2016 [16] | Austria | 40 | NA | Retrospective | Y | Hip, knee | MSIS (2013) | 13 |
Suda et al., 2017 [21] | Germany | 28 | 67.7 | Prospective | N | Hip, knee | MSIS (2013) | 13 |
Balato et al., 2018 [17] | Italy | 51 | 63 | Prospective | Y | Knee | MSIS (2013) | 12 |
Berger et al., 2017 [18] | Belgium | 121 | 63.5 | Prospective | N | Hip, knee | MSIS (2011) | 14 |
Gehrke et al., 2018 [23] | Germany | 191 | NA | Prospective | Y | Hip, knee | MSIS (2013) | 14 |
Plate et al., 2018 [26] | Switzerland | 109 | 65 | Prospective | Y | Hip, knee | MSIS (2013) | 13 |
de Saint Vincent et al., 2018 [22] | French | 39 | 62 | Prospective | N | Hip, knee | MSIS (2013) | 12 |
Riccio et al., 2018 [41] | Italy | 71 | 69 | Retrospective | N | Hip, knee | MSIS (2013) | 13 |
Sigmund et al., 2018 | Germany | 71 | 70 | Retrospective | Y | Hip, knee | MSIS (2013) | 13 |
Renz et al., 2018 [40] | Germany | 221 | 70 | Prospective | N | Hip, knee | MSIS (2013) | 14 |