From: Gout is not associated with the risk of fracture: a meta-analysis
Author | Year | Region | Data source | Study Design | Inclusion criteria | Inclusion interval | No. of patients | Drugs | |
---|---|---|---|---|---|---|---|---|---|
Urate-lowering group | Control group | ||||||||
Dennison, et al. [26] | 2015 | UK | Danish National Prescription Registry (DNPR) | Retrospective cohort study | All individuals who had at least one allopurinol prescription in the period from 1995 to 2011 in the Danish National Prescription Registry were identified. Patients were then further matched on quintiles of the propensity score to identify a more highly matched 1:1 control population. | 1995–2011 | 86039 | 86039 | Allopurinol |
Tzeng, et al. [23] | 2016 | China | Longitudinal Health Insurance Database (LHID) | Retrospective cohort study | Gout patients were diagnosed, and the age was > 20 years old; Non-gout patients were randomly selected from LHID enrollees without any histories of gouts, and the selection frequency was at 1:2 ratios of age and sex. | January 01, 2001–December 31, 2009; the data were followed until December 12, 2011 | 6264 3747 | 728 3245 | Allopurinol Benzbromarone |
Basu, et al. [28] | 2016 | UK | Dundee social work database | Prospective cohort study | Analyses were confined to those aged 65 and over; those with a hip fracture sustained prior to the date of discharge from rehabilitation were excluded. | January 2001–December 2011 | 1115 | 16153 | Allopurinol |
Sultan, et al. [1] | 2018 | UK | Clinical Practice Research Datalink | Retrospective cohort study | Gout patients were diagnosed based on a medical code assigned by the physician and the landmark analysis was used to examine the effect of urate-lowering therapy on the risk of first fracture among patients with gout. | 1990–2004; the data were followed until December 31, 2011 | 6750 | 24657 | Not mentioned |