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Table 3 Basic information of included studies

From: Gout is not associated with the risk of fracture: a meta-analysis

Author Year Region Data source Study Design Inclusion criteria Inclusion interval No. of patients Drugs
Urate-lowering group Control group
Dennison, et al. [26] 2015 UK Danish National Prescription Registry (DNPR) Retrospective cohort study All individuals who had at least one allopurinol prescription in the period from 1995 to 2011 in the Danish National Prescription Registry were identified. Patients were then further matched on quintiles of the propensity score to identify a more highly matched 1:1 control population. 1995–2011 86039 86039 Allopurinol
Tzeng, et al. [23] 2016 China Longitudinal Health Insurance Database (LHID) Retrospective cohort study Gout patients were diagnosed, and the age was > 20 years old; Non-gout patients were randomly selected from LHID enrollees without any histories of gouts, and the selection frequency was at 1:2 ratios of age and sex. January 01, 2001–December 31, 2009; the data were followed until December 12, 2011 6264 3747 728 3245 Allopurinol Benzbromarone
Basu, et al. [28] 2016 UK Dundee social work database Prospective cohort study Analyses were confined to those aged 65 and over; those with a hip fracture sustained prior to the date of discharge from rehabilitation were excluded. January 2001–December 2011 1115 16153 Allopurinol
Sultan, et al. [1] 2018 UK Clinical Practice Research Datalink Retrospective cohort study Gout patients were diagnosed based on a medical code assigned by the physician and the landmark analysis was used to examine the effect of urate-lowering therapy on the risk of first fracture among patients with gout. 1990–2004; the data were followed until December 31, 2011 6750 24657 Not mentioned