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Table 3 Basic information of included studies

From: Gout is not associated with the risk of fracture: a meta-analysis

Author

Year

Region

Data source

Study Design

Inclusion criteria

Inclusion interval

No. of patients

Drugs

Urate-lowering group

Control group

Dennison, et al. [26]

2015

UK

Danish National Prescription Registry (DNPR)

Retrospective cohort study

All individuals who had at least one allopurinol prescription in the period from 1995 to 2011 in the Danish National Prescription Registry were identified. Patients were then further matched on quintiles of the propensity score to identify a more highly matched 1:1 control population.

1995–2011

86039

86039

Allopurinol

Tzeng, et al. [23]

2016

China

Longitudinal Health Insurance Database (LHID)

Retrospective cohort study

Gout patients were diagnosed, and the age was > 20 years old; Non-gout patients were randomly selected from LHID enrollees without any histories of gouts, and the selection frequency was at 1:2 ratios of age and sex.

January 01, 2001–December 31, 2009; the data were followed until December 12, 2011

6264

3747

728

3245

Allopurinol

Benzbromarone

Basu, et al. [28]

2016

UK

Dundee social work database

Prospective cohort study

Analyses were confined to those aged 65 and over; those with a hip fracture sustained prior to the date of discharge from rehabilitation were excluded.

January 2001–December 2011

1115

16153

Allopurinol

Sultan, et al. [1]

2018

UK

Clinical Practice Research Datalink

Retrospective cohort study

Gout patients were diagnosed based on a medical code assigned by the physician and the landmark analysis was used to examine the effect of urate-lowering therapy on the risk of first fracture among patients with gout.

1990–2004; the data were followed until December 31, 2011

6750

24657

Not mentioned