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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Growth factor-mediated augmentation of long bones: evaluation of a BMP-7 loaded thermoresponsive hydrogel in a murine femoral intramedullary injection model

Fig. 1

Schematic representation of the VOIs selected for analysis of cortical and trabecular bone microarchitecture (a), the distal growth plate as an example of an anatomical landmark (b), representative images of the manually drawn ROIs for analysis of cortical (c), and trabecular (d) bone. The distal growth plate and the division into greater trochanter and femoral neck served as internal references, i.e., positioning of the VOIs for analysis of the distal and proximal femora as well as the femoral neck. For examination of the distal femur (1), VOI started 50 slices apart from the growth plate (b) and consisted of 100 slices. The VOI in the region diaphysis (2) started 400 slices apart from the growth plate and consisted of 100 slices. In case of the proximal femur (3), trab and cort VOIs consisted of 80 slices each and started 50 slices distal from the division into greater trochanter and femoral neck. For analysis of the femoral neck (4), cort VOI and trab VOI included 20 slices each and an offset of 15 slices from the division into greater trochanter and femoral neck was used

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