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Table 4 Microscopic evaluation of cartilage according to ICRS

From: Enhancement of cartilage repair through the addition of growth plate chondrocytes in an immature skeleton animal model

  1L 2P 3L 5P 6P 7P 8P 9P 10P 1P 2L 3P 5L 6L 7L 8L 9L 10L
Tissue morphology 68 65 62 71 50.5 40 52 52 60 88 88 84 82.5 45 39 55 80 65
Matrix staining 79 53 55 75.5 32 59 34 47 25 90 89 90 94 30 59 61 68 45
Cell morphology 80 55 80 70 26.5 75 36 54 52 84 79 86.5 91.5 44 56 61.5 62 57
Chondrocyte clustering 40 48 55 65 56 62 60 55 65 45 50 65 55 52 55 52 55 56
Surface architecture 90 79 78 51.5 79.5 96 79 89 79 96 89 88 81 81 82 90 96 90
Basal integration. 90 88 89 75 77.5 85 82 73 82 95 95 94 85 81 84 92 91 85
Formation of tidemark 25 24 30 36 18 22 21 25 21 35 44 42 44 20 34 30 44 38
Subchondral bone abnormalities 84 55 89 48 47 70 90 65 88 93.5 95 95.5 89 76.5 65 91.5 95 96
Inflammation 100 100 100 62.5 82 100 82 75 97 100 100 100 77 80.5 92 89 95 100
Abnormal calcification/ossification 100 100 100 87 100 100 100 100 100 100 100 100 100 100 100 100 100 100
Vascularization 86 20 95 70 52 50 42 45 70 100 92.5 96 94 50 48 55 95 75
Superficial assessment 81 60 72.5 70 45 72 62 62 80 92 91.5 91.5 91.5 38 67 60 72 75
Mid/deep zone assessment 80 62 75 75.5 61 75 71 66 76 89 92 89 82 75 50 83 84 85
Overall assessment 84 65 75 64 61 71 69 74 71 90 93 91.5 80 68 60 78 80 76
Scaffold with cells—CELLS           + + + + + + + + +
Scaffold without cells—CTRL + + + + + + + + +