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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway

Fig. 4

The pathways involved in H2O2-induced apoptosis in annulus fibrosus cells. a Western blot analysis to indicate the expressions of ERK1/2, JNK, and p38. b Flow cytometry analysis to investigate cell apoptosis after application of MAPK kinases blockers (ERK1/2: U0126, JNK: SP600125, p38: SB203580), caspase-3 blocker (Z-VAD-FMK), the mitochondrial pathway inhibitor (NS3694), and caspase-12 blocker (Z-ATAD-FMK). *P < 0.05; **P < 0.001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X