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Table 3 Stratified analyses between rs11564299 polymorphisms and the risk of osteoarthritis

From: CDH2 gene rs11564299 polymorphism is a risk factor for knee osteoarthritis in a Chinese population: a case–control study

Variable

rs11564299 (case/control)

AG vs. AA

GG vs. AA

GG vs. AA+AG

GG+AG vs. AA

 

AA

AG

GG

    

Sex

 Male

44/50

19/24

6/24

0.90 (0.44–1.86); 0.775

6.82 (0.79–58.80); 0.081

7.04 (0.83–60.06); 0.074

1.14 (0.57–2.26); 0.715

 Female

168/246

91/90

17/90

1.47 (1.04–2.09); 0.031

2.25 (1.03-4.92); 0.043

2.00 (0.92–4.34); 0.080

1.56 (1.11–2.18); 0.010

Smoking

 Yes

135/213

79/73

12/7

1.71 (1.16–2.51); 0.006

2.71 (1.04–7.04); 0.042

2.29 (0.89–5.92); 0.087

1.80 (1.24–2.60); 0.002

 No

78/83

31/41

11/5

0.81 (0.46–1.41); 0.446

2.34 (0.78–7.04); 0.130

2.50 (0.84–7.43); 0.099

0.97 (0.58–1.63); 0.914

Alcohol

 Yes

129/198

71/80

16/6

1.36 (0.92–2.01); 0.119

4.09 (1.56–10.73); 0.004

3.71 (1.43–9.63); 0.007

1.55 (1.07–2.25); 0.020

 No

84/98

39/34

7/6

1.34 (0.78–2.31); 0.294

1.36 (0.44–4.21); 0.592

1.25 (0.41–3.83); 0.694

1.34 (0.80–2.24); 0.263

Age (years)

 < 60

77/109

47/38

6/4

1.75 (1.04–2.94); 0.034

2.12 (0.58–7.78); 0.256

1.78 (0.49–6.44); 0.381

1.79 (1.08–2.94); 0.023

 ≥ 60

136/187

63/75

17/8

1.14 (0.76–1.70); 0.522

2.92 (1.23–6.97); 0.016

2.81 (1.19–6.64); 0.019

1.31 (0.90–1.91); 0.162

BMI

 < 25

75/94

43/44

6/4

1.23 (0.73–2.06); 0.443

1.88 (0.51–6.91); 0.342

1.75 (0.48–6.37); 0.392

1.28 (0.78–2.11); 0.335

 ≥ 25

138/202

67/70

17/8

1.40 (0.94–2.09); 0.098

3.11 (1.31–7.41); 0.010

2.82 (1.19–6.66); 0.018

1.58 (1.08–2.30); 0.018

  1. Values in italics are statistically significant (P < 0.05)