Table 3 Stratified analysis of rs8040868 polymorphisms of CHRNA3 gene by gender and risk of LDH
From: CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study
Group | Variants | OR (95%CI) | p | Group | Variants | OR (95%CI) | p |
|---|---|---|---|---|---|---|---|
≤ 50 | Age | 0.91 (0.87–0.96) | < 0.001 | > 50 | Age | 1.07 (1.02–1.11) | 0.004 |
Smoking | 0.17 (0.07–0.43) | < 0.001 | Smoking | 0.11 (0.06–0.24) | < 0.001 | ||
Drinking | 0.05 (0.02–0.15) | < 0.001 | Drinking | 0.07 (0.03–0.18) | < 0.001 | ||
Gender | 0.07 (0.03–0.13) | < 0.001 | Gender | 0.52 (0.29–0.94) | 0.032 | ||
rs8040868-TT | 1 | rs8040868-TT | 1 | ||||
rs8040868-CT | 1.11 (0.44–2.79) | 0.819 | rs8040868-CT | 1.02 (0.43–2.41) | 0.96 | ||
rs8040868-CC | 0.64 (0.25–1.64) | 0.351 | rs8040868-CC | 1.07 (0.45–2.5) | 0.883 | ||
Age | 0.91 (0.87–0.96) | < 0.001 | Age | 1.07 (1.02–1.11) | 0.004 | ||
Smoking | 0.17 (0.07–0.42) | < 0.001 | Smoking | 0.11 (0.06–0.24) | < 0.001 | ||
Drinking | 0.05 (0.02–0.15) | < 0.001 | Drinking | 0.07 (0.03–0.18) | < 0.001 | ||
Gender | 0.07 (0.03–0.13) | < 0.001 | Gender | 0.52 (0.29–0.95) | 0.032 | ||
rs8040868-TT VS. (CT + CC) | 0.63 (0.37–1.07) | 0.084 | rs8040868-TT VS. (CT + CC) | 1.03(0.62–1.71) | 0.909 | ||
Age | 0.91 (0.87–0.96) | < 0.001 | Age | 1.07 (1.02–1.11) | 0.004 | ||
Smoking | 0.17 (0.07–0.42) | < 0.001 | Smoking | 0.11 (0.06–0.24) | < 0.001 | ||
Drinking | 0.05 (0.02–0.16) | < 0.001 | Drinking | 0.07 (0.03–0.18) | < 0.001 | ||
Gender | 0.07 (0.03–0.13) | < 0.001 | Gender | 0.52 (0.29–0.94) | 0.032 | ||
rs8040868-(TT + CT)VS.CC | 1.16(0.48–2.8) | 0.749 | rs8040868-(TT + CT)VS.CC | 0.96 (0.43–2.16) | 0.916 | ||
Male | Age | 0.94 (0.91–0.97) | < 0.001 | Female | Age | 1.08 (1.05–1.11) | < 0.001 |
Smoking | 0.12 (0.06–0.21) | < 0.001 | Smoking | / | 0.999 | ||
Drinking | 0.05 (0.03–0.11) | < 0.001 | Drinking | / | 0.999 | ||
rs8040868-TT | 1 | rs8040868-TT | 1 | 0.769 | |||
rs8040868-CT | 0.46 (0.25–0.84) | 0.012 | rs8040868-CT | 1.12 (0.68–1.85) | 0.649 | ||
rs8040868-CC | 0.75 (0.28–2.03) | 0.572 | rs8040868-CC | 1.32 (0.59–2.98) | 0.502 | ||
Age | 0.94( 0.92–0.97) | < 0.001 | Age | 0.94 (0.92–0.97) | < 0.001 | ||
Smoking | 0.12 (0.06–0.21) | < 0.001 | Smoking | 0.12 (0.06–0.21) | < 0.001 | ||
Drinking | 0.06 (0.03–0.11) | < 0.001 | Drinking | 0.06 (0.03–0.11) | < 0.001 | ||
rs8040868-TT VS. (CT + CC) | 0.5(0.28–0.89) | 0.019 | rs8040868-TT VS. (CT + CC) | 0.50 (0.28–0.89) | 0.019 | ||
Age | 0.94 (0.91–0.97) | < 0.001 | Age | 1.08 (1.05–1.11) | < 0.001 | ||
Smoking | 0.11 (0.06–0.2) | < 0.001 | Smoking | / | 0.999 | ||
Drinking | 0.06 (0.03–0.12) | < 0.001 | Drinking | / | 0.999 | ||
rs8040868-(TT + CT)VS.CC | 1.11 (0.44–2.85) | 0.821 | rs8040868-(TT + CT)VS.CC | 1.25 (0.57–2.72) | 0.573 |