CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study

Table 2 Allele frequencies in cases and controls and OR estimates for LDH

SNP ID	Gene	Alleles A/B	Case			Control			MAF		HWE, p †	Allele model
SNP ID	Gene	Alleles A/B	AA count	AB count	BB count	AA count	AB count	BB count	Case	Control	HWE, p †	OR (95% CI)	p ‡
rs667282	CHRNA5	C/T	90	187	102	91	196	113	0.484	0.473	0.764	1.05 (0.86–1.28)	0.645
rs16969948	CHRNA5	G/A	1	39	339	2	42	356	0.054	0.058	0.377	0.94 (0.61–1.45)	0.770
rs588765	CHRNA5	T/C	15	133	232	17	121	262	0.214	0.194	0.523	1.14 (0.89–1.45)	0.310
rs6495306	CHRNA5	G/A	15	132	232	17	121	262	0.214	0.194	0.523	1.13 (0.88–1.45)	0.328
rs17486278	CHRNA5	C/A	27	133	219	29	163	208	0.247	0.276	0.803	0.86 (0.68–1.08)	0.185
rs680244	CHRNA5	T/C	27	151	202	26	149	224	0.270	0.252	0.894	1.10 (0.87–1.38)	0.422
rs569207	CHRNA5	T/C	94	185	100	91	196	113	0.492	0.473	0.764	1.08 (0.89–1.32)	0.439
rs692780	CHRNA5	C/G	18	131	231	19	124	257	0.220	0.203	0.438	1.11 (0.87–1.42)	0.404
rs3743077	CHRNA3	T/C	21	140	219	21	136	243	0.239	0.223	0.772	1.10 (0.87–1.39)	0.426
rs1317286	CHRNA3	G/A	5	61	314	6	64	330	0.093	0.095	0.150	0.98 (0.70–1.38)	0.915
rs938682	CHRNA3	G/A	87	179	114	78	196	125	0.464	0.441	1.000	1.10 (0.90–1.34)	0.354
rs12914385	CHRNA3	T/C	25	136	219	26	165	209	0.245	0.271	0.448	0.87 (0.69–1.09)	0.232
rs2869546	CHRNA3	C/T	19	139	222	20	135	242	0.233	0.220	0.884	1.07 (0.85–1.36)	0.557
rs3743075	CHRNA3	T/C	71	183	117	92	181	123	0.438	0.461	0.107	0.91 (0.75–1.12)	0.369
rs8040868	CHRNA3	C/T	36	157	186	40	186	174	0.302	0.333	0.369	0.87 (0.70–1.08)	0.198

LDH lumbar disc herniation, SNP single-nucleotide polymorphism, MAF minor allele frequency, HWE Hardy–Weinberg equilibrium, OR odds ratio, 95% CI 95% confidence interval
† p was calculated by exact test
‡ p was calculated by Pearson chi-squared test

ISSN: 1749-799X