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Table 2 Histology of anterior horn and intermediate gray matter of spinal cord in 7 different time points, from 10 min till 360 days, after spinal cord injury

From: Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

Treatment group   Time after spinal cord injury (min/med/max)
10 min. 7 days 15 days 30 days 90 days 180 days 360 days
Control
saline 5 ml/kg b.w. i.p.
Hemorrhage 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Edema 0/0/0 1/1.5/2 1/3/3 3/3/3 3/3/3 3/3/3 3/3/3
Necrosis 0/0/0 1/1.5/2 1/3/3 3/3/3 3/3/3 3/3/3 3/3/3
Pentadecapeptide BPC 157 200 μg/kg b.w. i.p. Hemorrhage 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Edema 0/0/0 0/1/1 0/1/1* 0/1/3* 1/1/1* 1/1/1* 2/2/2*
Necrosis 0/0/0 0/1/1 1/1/1 0/1/3* 0/0/2* 3/3/3 3/3/3
Pentadecapeptide BPC 157 2 μg/kg b.w. i.p. Hemorrhage 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Edema 0/0/0 0/1/1 0/0/2* 1/2/2* 1/1/1* 1/1/1* 2/2/2*
Necrosis 0/0/0 1/1/1 0/0/3 1/2/2* 0/0/2* 3/3/3 3/3/3
Laminectomy Hemorrhage 0/0/0
Edema 0/0/0
Necrosis 0/0/0
  1. Semiquantitatively evaluated intensity of (a) hemorrhagic zone, (b) edema, and (c) loss of neurons in anterior horn and intermediate gray matter of spinal cord (0—no changes; 1—small or focal changes; 2—moderate changes; 3—numerous confluent changes)
  2. *Statistically significant difference between both pentadecapeptide BPC 157 groups and control group, P < 0.025