Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

Table 1 Histology of lateral and posterior columns of spinal cord in 7 different time points, from 10 min till 360 days, after spinal cord injury

Treatment group		Time after spinal cord injury (min/med/max)
Treatment group		10 min.	7 days	15 days	30 days	90 days	180 days	360 days
Control saline 5 ml/kg b.w. i.p.	Hemorrhage	2/2.5/3	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0
	Vacuoles	0/0/0	2/2.5/3	1/3/3	2/2/2	2/2/2	2/2.5/3	2/2.5/3
	Necrosis	0/0/0	1/2.5/3	2/3/3	2/3/3	2/3/3	1/3/3	1/3/3
Pentadecapeptide BPC 157 200 μg/kg b.w. i.p.	Hemorrhage	2/2.5/3	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0
	Vacuoles	0/0/0	1/1/1*	1/1/1*	0/1/2*	1/1/1*	1/1/2*	1/2/2*
	Necrosis	0/0/0	0/2/2	0/0/2*	1/1/2*	0/0/1*	1/1/1*	0/0/1
Pentadecapeptide BPC 157 2 μg/kg b.w. i.p.	Hemorrhage	2/2.5/3	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0	0/0/0
	Vacuoles	0/0/0	1/1/1*	1/1/1*	0/1/2*	1/1/1*	1/1/2*	1/2/2*
	Necrosis	0/0/0	0/2/2	0/0/2*	1/1/2*	0/0/1*	1/1/1*	0/0/1
Laminectomy	Hemorrhage	–	–	–	–	–	–	0/0/0
	Vacuoles	–	–	–	–	–	–	0/0/0
	Necrosis	–	–	–	–	–	–	0/0/0

Semiquantitatively evaluated intensity of (a) hemorrhagic zone, (b) vacuoles, and (c) loss of tracts in lateral and posterior columns of spinal cord (0—no changes; 1—small or focal changes; 2—moderate changes; 3—numerous confluent changes)
*Statistically significant difference BPC 157 groups vs control group, P < 0.025

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