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Table 1 Histology of lateral and posterior columns of spinal cord in 7 different time points, from 10 min till 360 days, after spinal cord injury

From: Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

Treatment group   Time after spinal cord injury (min/med/max)
10 min. 7 days 15 days 30 days 90 days 180 days 360 days
Control
saline 5 ml/kg b.w. i.p.
Hemorrhage 2/2.5/3 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Vacuoles 0/0/0 2/2.5/3 1/3/3 2/2/2 2/2/2 2/2.5/3 2/2.5/3
Necrosis 0/0/0 1/2.5/3 2/3/3 2/3/3 2/3/3 1/3/3 1/3/3
Pentadecapeptide BPC 157 200 μg/kg b.w. i.p. Hemorrhage 2/2.5/3 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Vacuoles 0/0/0 1/1/1* 1/1/1* 0/1/2* 1/1/1* 1/1/2* 1/2/2*
Necrosis 0/0/0 0/2/2 0/0/2* 1/1/2* 0/0/1* 1/1/1* 0/0/1
Pentadecapeptide BPC 157 2 μg/kg b.w. i.p. Hemorrhage 2/2.5/3 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0 0/0/0
Vacuoles 0/0/0 1/1/1* 1/1/1* 0/1/2* 1/1/1* 1/1/2* 1/2/2*
Necrosis 0/0/0 0/2/2 0/0/2* 1/1/2* 0/0/1* 1/1/1* 0/0/1
Laminectomy Hemorrhage 0/0/0
Vacuoles 0/0/0
Necrosis 0/0/0
  1. Semiquantitatively evaluated intensity of (a) hemorrhagic zone, (b) vacuoles, and (c) loss of tracts in lateral and posterior columns of spinal cord (0—no changes; 1—small or focal changes; 2—moderate changes; 3—numerous confluent changes)
  2. *Statistically significant difference BPC 157 groups vs control group, P < 0.025