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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Autologous cell-coated particles for the treatment of segmental bone defects—a new cell therapy approach

Fig. 1

Surgical procedure. a To expose the bone, a longitudinal incision of 10–12 cm was made along the posterior–lateral aspect of the right tibia and a 4.5 stainless steel plate with 8–10 holes was adjusted to the morphology of the bone. b The plate was fixed to the posterior aspect of the tibia with 4.5 mm trans-cortical screws, 4 proximal screws, and 4 distal screws, leaving a central space of 3.5 cm. c, d A 3.2-cm cylinder was cut out of the tibia. e Two weeks following the first procedure, a limited incision just above the gap was performed. Then, a V wedge-shaped canal, about 5-mm deep and 3-mm wide, was cut across the regeneration scar tissue that filled the gap out all along the gap. f BonoFill-II injectable formulation (10 ml) was injected into the canal

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