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Table 1 Microarchitectural quantitative analysis results of an ROI in the femur trabecular bone

From: Combined low-dose LiCl and LY294002 for the treatment of osteoporosis in ovariectomized rats

 

Control

OVX

LiCl

Ly294002

LiCl + ly294002

BMD (mg HA/ccm)

651.93 ± 15.5

503.46 ± 14.3**

569.76 ± 13.6**##

577.07 ± 15.8**##

605.72 ± 14.1**##□□

BV/TV (%)

0.2734 ± 0.03

0.0384 ± 0.01**

0.0863 ± 0.01**##

0.08 ± 0.01**##

0.1352 ± 0.02**##□□

SMI

1.1439 ± 0.1762

2.7716 ± 0.2553**

2.3604 ± 0.231**##

2.5083 ± 0.2275**##

2.0728 ± 0.1931**##□

COD (mm−3)

170.4669 ± 13.0462

14.1078 ± 1.437**

57.0813 ± 4.1097**##

46.9949 ± 3.7431**##

81.2214 ± 5.9857**##□□

BS/BV (mm−1)

35.685 ± 1.04

50.2093 ± 3.98**

48.7623 ± 2.6**

48.4133 ± 2.81**

46.5063 ± 2.22**##

Tb.N (mm−1)

4.7613 ± 0.41

0.9894 ± 0.08**

2.0506 ± 0.17**##

1.9949 ± 0.15**##

3.5802 ± 0.28**##□□

Tb.Sp (mm)

0.1952 ± 0.014

1.0327 ± 0.072**

0.4933 ± 0.032**##

0.5059 ± 0.041**##

0.2699 ± 0.019**##□□

Tb.Th (mm)

0.0712 ± 0.006

0.0569 ± 0.004**

0.0556 ± 0.004**

0.0581 ± 0.004**

0.0585 ± 0.004**

  1. BMD, mg HA/cm3; BV/TV, %; SMI, a method for determining the plate- or rod-like geometry of trabecular structures; COD, the number of connections in the trabecular network, which is decreased in osteoporosis; BS/BV, 1/mm; Tb.N, 1/mm; Tb.Sp, mm; Tb.Th, mm. The statistical results shown represent the mean ± standard (n = 7) vs the control group, *P < 0.05, **P < 0.01; vs the OVX group, #P < 0.05, ##P < 0.01; vs the LiCl group, P < 0.05, □□P < 0.01; vs the ly294002 group, P < 0.05, P < 0.01