A preliminary study of the novel antibiotic-loaded cement computer-aided design-articulating spacer for the treatment of periprosthetic knee infection

Tsai, Chun-Hao; Hsu, Horng-Chaung; Chen, Hui-Yi; Fong, Yi-Chin; Ho, Mao-Wang; Chou, Chia-Huei; Chen, Yi-Wen; Shie, Ming-You; Lin, Tsung-Li

doi:10.1186/s13018-019-1175-0

Journal of Orthopaedic Surgery and Research

Table 1 Patient clinical data

From: A preliminary study of the novel antibiotic-loaded cement computer-aided design-articulating spacer for the treatment of periprosthetic knee infection

Case no.	Age (year)/sex	Initial visit		Causative agent(s)	Spacer		Interval (month)	Post-reimplantation		Result	Infection eradication	Follow-up (month)
Case no.	Age (year)/sex	Knee score	ROM (degree)	Causative agent(s)	Knee score	ROM (degree)	Interval (month)	Knee score	ROM (degree)	Result	Infection eradication	Follow-up (month)
1	67/M	34	10–80	MRSA	66	5–95	5.5	83.6	0–100	Reimplantation	Y	45
2	63/M	46.6	5–20	MSSA	68	10–45	4	86.3	5–85	Reimplantation	Y	44.8
3	67/F	26	5–95	MSSA	78.8	5–90	4.5	88.2	0–103	Reimplantation	Y	44
4	84/F	22	20–60	Unknown	68	12–85				Spacer	Y	43.5
5	74/F	32.3	3–103	S. epidermidis	62	5–100	4.5	90	3–105	Reimplantation	Y	42.3
6	73/F	36	5–95	S. dysgalactiae	60.2	0–100	8.5	85.2	0–108	Reimplantation	Y	41.8
7	68/M	32	3–97	C. koseri	69.3	5–100	2*			Resection	N	40.8
8	88/F	38	10–87	MSSA	66.2	6–95				Spacer	Y	40.2
9	62/M	28	12–83	MSSA	64	2–90	4.5	88.3	0–94	Reimplantation	Y	39.6
10	71/M	42.8	6–100	Unknown	67	10–120	5.5	80.2	3–125	Reimplantation	Y	39.2
11	77/F	38	5–90	MSSA	66.5	6–116	6	78	2–120	Reimplantation	Y	38.5
12	68/M	20	30–50	MRSA + P. aeruginosa	60	20–68	3.5	81.2	5–85	Reimplantation	Y	38.2
13	71/F	36.7	12–85	E. coli	70.2	5–108	5.5	83.2	0–112	Reimplantation	Y	38
14	58/F	42	5–90	Unknown	62.2	10–95	6	86	5–103	Reimplantation	Y	37.8
15	93/M	20	70–85	E. cloacae	64	45–95				Spacer	Y	37.3
16	85/M	22	13–92	S. haemilyticus	63.5	10–90				Spacer	Y	37.1
17	72/M	22.2	8–90	Unknown	67	10–100	1.5*			Resection	N	36.7
18	70/F	34	5–96	S. salivarius	65	8–100	5	82.1	5–108	Reimplantation	Y	36.4
19	65/F	24	30–80	C. striatum	61	6–90	4.5	83.6	2–95	Reimplantation	Y	36.2
20	63/M	26.6	13–85	P. aeruginosa	60.8	10–95	2.5*			Resection	N	35.6
21	66/F	32	3–95	VRE	61.2	0–110	12.5	80.4	0–115	Reimplantation	Y	34.4
22	86/M	42	5–93	E. coli	64.5	5–103				Spacer	Y	34
23	71/M	20.1	20–75	MRSA + E. cloacae	68.6	20–77	3.8*			Amputation	N	33.8
24	76/F	23	3–92	MRSA	64	6–100				Spacer	Y	33.5
25	78/M	33	10–90	P. aeruginosa	63	8–96				Spacer	Y	33.5
26	62/F	39	5–85	E. cloacae	67.5	5–95	6.3	82.3	0–108	Reimplantation	Y	32.4
27	81/F	36	10–85	E. coli	66	5–102				Spacer	Y	32.3
28	89/M	23	6–85	Unknown	69.4	4–96				Spacer	Y	32
29	85/F	20	30–65	MSSA + S. dysgalactiae	61	25–85				Spacer	Y	31.8
30	70/M	48	5–93	MSSA	68	5–100	4.2	84.2	3–110	Reimplantation	Y	31.4
31	72/F	30.5	6–84	MRSA	64	3–88	4.5	83.6	0–95	Reimplantation	Y	30.8
32	63/F	27.7	12–86	MSSA	67.2	10–90	6.4	89.6	4–102	Reimplantation	Y	30.1
Average	70.4	31.2	72.0		65.4	85.6	8.8	84.2	102.0			36.9

M, male; F, female; ROM, range of motion; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; S. epidermidis, Staphylococcus epidermidis; S. dysgalactiae, Streptococcus dysgalactiae; C. koseri, Citrobacter koseri; P. aeruginosa, Pseudomonas aeruginosa; E. coli, Escherichia coli; E. cloacae, Enterobacter cloacae; S. haemolyticus, Staphylococcus haemolyticus; S. salivarius, Streptococcus salivarius; C. striatum, Corynebacterium striatum; VRE, vancomycin-resistant Enterococci; Y, yes; N, no
*Four cases with reinfection were ruled out for calculation of the average interim period

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ISSN: 1749-799X

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