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Table 2 Study intervention protocol of RCTs included in the meta-analysis

From: An updated meta-analysis evaluating limb management after total knee arthroplasty—what is the optimal method?

Studies Country Intervention method Approach Tourniquet Drain TXA Prophylactic anticoagulation TT
Flexion Extension
Knee Hip Time Knee Hip
Ong 2003 [42] the UK 70° 35° 6 h FE NA Yes Yes NA Enoxaparin or aspirin 8 g/dl
Ma 2008 [27] Australia 70° 70° 24 h FE MP NA Yes NA Enoxaparin 20 mg NA
Li 2017 [24] China < 30° LE-25 72 h FE LE-25 NA Yes Yes NA LMWH 8 g/dl
Liu 2015 [22] China 45° 45° 48 h FE NA MP No No NA Enoxaparin 40 mg 8 g/dl
Zeng 2018 [26] China 90–60° NA 24 h FE NA MP Yes Yes Yes LMWH 7 g/dl
Panni 2014 [25] Italy 90° 45° 6 h FE NA MP Yes Yes Yes 4000 IU LMWH 8 g/dl
Yang 2015 [23] China 60° 60° 48 h FE NA MP No Yes Yes LMWH 9 g/d
Antinolfi 2014 [28] Italy 90–50° NA 6 h FE NA MIP Yes Yes NA 4000 IU LMWH NA
Napier 2014 I [20] the UK 120° NA 6 h FE NA MP Yes No No Aspirin 150 mg 7 g/dl
Napier 2014 II [20] the UK 120° NA 6 h FE NA MP Yes No No Aspirin 150 mg 7 g/dl
Li 2012 [21] China 30° 30° 72 h FE 30° MV No No NA LMWH 9 g/dl
Zhao 2014 [36] China 30° 45° 24 h FE MP Yes Yes NA Rivaroxaban(10 mg/d) 9 g/dl
Shen 2016 [38] China 70° 45° 12 h FE NA NA Yes NA NA NA
Hu 2013 [35] China 70° 45° 12 h FE NA Yes Yes NA Rivaroxaban(10 mg/d) NA
Li 2016 [39] China 45° 45° 48 h FE NA MP Yes Yes NA Enoxaparin 0.4 ml 7 g/dl
Guo 2013 [37] China 70° 30° 6 h FE MP Yes Yes NA Rivaroxaban(10 mg/d) 8 g/dl
Peng 2016 I [34] China 30° 30° 72 h FE 30° MP Yes Yes NA Rivaroxaban(10 mg/d) NA
Peng 2016 II [34] China 60° 30° 72 h FE 30° MP Yes Yes NA Rivaroxaban(10 mg/d) NA
  1. Abbreviations: LE-25 leg elevated 25 cm, 90–60° 90° flexion position for the first 12 h and 60° flexion position for the next 12 h, 90–50° 90° flexion position for the first 3 h and 50° flexion position for the next 3 h, FE full extension, NA not available, MP medial parapatellar approach, MIP modified Insallr approach, MV mid-vastus approach, LMWH low molecular weight heparin, TXA tranexamic acid, TT transfusion trigger