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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

Fig. 7

Schematic mechanism for Brd-mediated transcriptional regulation of MMP1, MMP3, MMP13, and ADAMTS4 genes in human chondrycytes. This model proposes that IL-1β or TNF-α stimulation leads to the H4K5/8/12Ac at TSS regions and the recruitment of Brd3, Brd4, and p-TEFb to these regions. Subsequently, Ser2 RNAP II CTD is phosphorylated by p-TEFb. The recruitment of Brd3 and Brd4 is blocked by I-BET-151

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X