Skip to main content
Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

Fig. 1

The effect of I-BET151 on regulation of matrix-degrading enzyme gene transcription in SW1353 cells. ad The transcriptional expression (RT-PCR) of MMP1, MMP3, MMP13, and ADAMTS4 genes in SW1353 cells, respectively, after the cells were pretreated with or without I-BET151 (1 μM) followed by addition of vehicle, IL-1β (10 ng/ml) or TNF-α (10 ng/ml) for 6 h. Relative fold-change values were calculated in comparison with vehicle control that was set to 1 (n = 3)

Back to article page