Table 1 Concentrations of oritavancin eluted from 7.5% w/w oritavancin polymethylmethacrylate (PMMA) beads prepared using three methods
From: Oritavancin polymethylmethacrylate (PMMA)—compressive strength testing and in vitro elution
Sample | Mean (n = 3) measured concentration (μg/ml) | Standard deviation (n = 3) (μg/ml) |
|---|---|---|
PMMA alone (negative control) | Below quantifiable limit | Not applicable |
PMMA + oritavancin | 2.7 | 0.07 |
PMMA + oritavancin + polysorbate 80 | 3.0 | 0.08 |
Oritavancin pre-coated molda | 7.0 | 0.17 |
Oritavancin in plasma, no PMMA (positive control) | 62.3 | 1.2 |