Fig. 4

The data screening process of whole-exon sequencing revealed variants (a). Sanger sequencing chromatograms of family members who are heterozygous (b) and homozygous (c) for the WISP3 variant. Amino acid conservation map across species demonstrating a highly conserved residue at position 132 (d, based on Multiz Alignments Track of UCSC Genome Browser and the human genome reference hg19/GRCch37)