Table 2 Core pathways and their associated genes found
GOID | GO term | Term P value | % associated genes | Associated genes found |
|---|---|---|---|---|
GO:0000650 | Butanoate metabolism | 0.02 | 10.71 | [ACSM2B, ACSM4, ACSM6] |
GO:0002010 | ABC transporters | 0.01 | 8.89 | [ABCA3, ABCD1, ABCG2, ABCG4] |
GO:0004330 | Notch signaling pathway | 0.02 | 8.33 | [JAG2, MAML3, MFNG, NOTCH1] |
GO:0000590 | Arachidonic acid metabolism | 0.04 | 6.45 | [CYP2B6, CYP2E1, PTGS1, TBXAS1] |
GO:0004340 | Hedgehog signaling pathway | 0.07 | 6.38 | [BCL2, IHH, PTCH2] |
GO:0004514 | Cell adhesion molecules (CAMs) | 0.00 | 6.21 | [CD22, CD226, CD86, CLDN15, ITGAM, NCAM2, NLGN1, PTPRC, VCAM1] |
GO:0004917 | Prolactin signaling pathway | 0.05 | 5.71 | [CISH, MAPK10, PRL, TH] |
GO:0005217 | Basal cell carcinoma | 0.10 | 5.45 | [PTCH2, TCF7L2, WNT10A] |
GO:0004658 | Th1 and Th2 cell differentiation | 0.04 | 5.43 | [IL12RB1, JAG2, MAML3, MAPK10, NOTCH1] |
GO:0004080 | Neuroactive ligand-receptor interaction | 0.00 | 5.40 | [AVPR2, CHRNB3, CHRNE, CYSLTR1, EDNRB, GABBR1, GIPR, GLP2R, HRH3, LTB4R, NMUR2, NPY2R, NPY4R, OPRL1, PRL] |
GO:0004728 | Dopaminergic synapse | 0.02 | 5.38 | [CACNA1C, CALML6, GNG13, KCNJ6, MAPK10, SCN1A, TH] |
GO:0004610 | Complement and coagulation cascades | 0.07 | 5.06 | [F7, ITGAM, MASP2, VWF] |
GO:0005210 | Colorectal cancer | 0.12 | 5.00 | [BCL2, MAPK10, TCF7L2] |
GO:0004742 | Taste transduction | 0.09 | 4.82 | [CACNA1C, GABBR1, GNG13, SCN2A] |
GO:0004911 | Insulin secretion | 0.09 | 4.71 | [CACNA1C, FFAR1, GCG, KCNU1] |
GO:0005214 | Glioma | 0.14 | 4.69 | [CALML6, PDGFB, PLCG2] |
GO:0000830 | Retinol metabolism | 0.14 | 4.62 | [ADH6, CYP2B6, DHRS4L1] |
GO:0004727 | GABAergic synapse | 0.10 | 4.55 | [CACNA1C, GABBR1, GNG13, KCNJ6] |
GO:0000010 | Glycolysis/gluconeogenesis | 0.15 | 4.48 | [ACSS1, ADH6, LDHC] |
GO:0005031 | Amphetamine addiction | 0.16 | 4.41 | [CACNA1C, CALML6, TH] |
GO:0004020 | Calcium signaling pathway | 0.03 | 4.40 | [ATP2A1, ATP2B3, CACNA1C, CALML6, CYSLTR1, EDNRB, GNA14, PLCG2] |
GO:0004022 | cGMP-PKG signaling pathway | 0.05 | 4.29 | [ATP2A1, ATP2B3, CACNA1C, CALML6, EDNRB, KCNU1, NPPB] |
GO:0000982 | Drug metabolism | 0.17 | 4.29 | [ADH6, CYP2B6, CYP2E1] |
GO:0004662 | B cell receptor signaling pathway | 0.17 | 4.23 | [CD22, PLCG2, RASGRP3] |
GO:0005418 | Fluid shear stress and atherosclerosis | 0.07 | 4.23 | [BCL2, CALML6, MAPK10, PDGFB, PIAS4, VCAM1] |
GO:0004064 | NF-kappa B signaling pathway | 0.12 | 4.21 | [BCL2, PIAS4, PLCG2, VCAM1] |
GO:0004713 | Circadian entrainment | 0.13 | 4.17 | [CACNA1C, CALML6, GNG13, KCNJ6] |
GO:0004915 | Estrogen signaling pathway | 0.14 | 4.08 | [CALML6, GABBR1, HSPA6, KCNJ6] |
GO:0000980 | Metabolism of xenobiotics by cytochrome P450 | 0.19 | 4.05 | [ADH6, CYP2B6, CYP2E1] |
GO:0004024 | cAMP signaling pathway | 0.06 | 4.04 | [ATP2B3, CACNA1C, CALML6, FXYD1, GABBR1, GHRL, GIPR, MAPK10] |
GO:0004933 | AGE-RAGE signaling pathway in diabetic complications | 0.14 | 4.04 | [BCL2, MAPK10, PLCG2, VCAM1] |