Adjacent segment degeneration or disease after cervical total disc replacement: a meta-analysis of randomized controlled trials

Table 1 Characteristics of the included studies

References	Design	Intervention		Patients		Level		Age(years)		FU (months)	ASDeg		ASDis		Reoperation		Quality^a
References	Design	F	NF	F	NF	F	NF	F	NF	FU (months)	F	NF	F	NF	F	NF	Quality^a
Phillips, F M(US) [31]	RCT (R:1:1 C:unclear B:unclear L:114/403)	ACDF	TDR (PCM)	185	218	S	S	comparable		60	92	72			11	4	B
Davis, R J(US) [30]	RCT (R:ratio1:2 C:Yes B:patients L:18/330)	ACDF	TDR (Mobi-C)	105	225	D	D	46.2	45.3	48	48	92					B
Zhang, H X(CHA) [29]	RCT (R:ratio1:1 C:unclear B:unclear L:0/111)	ACDF	TDR (Mobi-C)	56	55	S	S	46.7	44.8	48					4	0	B
Burkus, J K(US) [28]	RCT (R:ratio1:1 C:Yes B:patients L:146/541)	ACDF	TDR (Prestige)	265	276	S	S	43.9	43.3	84					10	8	B
Li, Z H(CHA) [27]	RCT (R:ratio1:1 C:unclear B:unclear L:0/81)	ACDF	TDR (Scient’x)	42	39	S	S	49.5	45.3	27	6	5					C
Guan, T (CHA) [26]	RCT (R:ratio1:1 C:unclear B:unclear L:6/66)	ACDF	TDR (Active-c)	34	32	S	S	52.6	49.6	34	21	13					B
Tian, W(CHA) [25]	RCT (R:ratio1:1 C:unclear B:unclear L:30/93)	ACDF	TDR (Bryan)	48	45	S/D (23/12)	S/D (20/8)	48.7	45	80	21	12					B
Nunley, P D(US) [24]	RCT (R:ratio1:2 C:unclear B:Patients L:12/182)	ACDF	TDR (unclear)	62	120	S/D (43/19)	S/D (71/29)	43	45	42	18	31	9	19			C
Coric, D(US) [23]	RCT (R:ratio1:1 C:unclear B:unclear L:35/269)	ACDF	TDR (Kineflex-C)	133	136	S	S	43.9	43.7	24	68	42			5	1	B
Sasso, R C(US) [22]	RCT (R:ratio1:1 C:Yes B:Both L:154/463)	ACDF	TDR (Bryan)	221	242	S	S	46.1	42.5	48			9	9	9	9	A
Jawahar, A(US) [17]	RCT (R:randomization number C:unclear B:Patients L:29/93)	ACDF	TDR (Kineflex-C/Mobi-C/Advent)	34	59	S/D (28/6)	S/D (43/16)	comparable		37			6	9			B

Abbreviations: RCT randomized controlled trial, R randomization, C concealment of allocation, B blinding, L losses to follow-up, ACDF anterior cervical discectomy and fusion, TDR total disc replacement, S single level, D double levels, FU follow-up, ASDeg adjacent segment degeneration, ASDis adjacent segment disease
^aQuality was classified as A level (A), B level (B), or C level (C) by Cochrane Handbook for Systematic Reviews of Interventions

ISSN: 1749-799X