Table 4 Pooled results on the association between SMAD3 rs12901499 polymorphism and OA risk in Asians
Genetic model | No. of studies | Test of association | Statistical model | Test of heterogeneity | ||
|---|---|---|---|---|---|---|
OR (95% CI) | p | I2 (%) | p | |||
Allele model (G vs. A) | 5 | 1.28 (0.87–1.88) | 0.203 | Random | 90.1 | 0.000 |
Dominant model (GG+AG vs. AA) | 5 | 1.18 (0.70–2.00) | 0.529 | Random | 90.2 | 0.000 |
Recessive model (GG vs. AG+AA) | 5 | 1.29 (0.90–1.86) | 0.166 | Random | 85.3 | 0.000 |
Homozygote model (GG vs. AA) | 5 | 1.21 (0.83–1.77) | 0.324 | Random | 70.6 | 0.009 |
Heterozygote model (AG vs. AA) | 5 | 1.06 (0.56–1.99) | 0.857 | Random | 92.3 | 0.000 |