Table 3 Pooled results on the association between SMAD3 rs12901499 polymorphism and OA risk
Genetic model | Sub-group | No. of studies | Test of association | Statistical model | Test of heterogeneity | ||
|---|---|---|---|---|---|---|---|
OR (95% CI) | p | I2 (%) | p | ||||
Allele model (G vs. A) | Overall | 10 | 1.21 (1.07–1.38) | 0.003 | Random | 75.4 | 0.000 |
Ethnicity | |||||||
Asian | 5 | 1.24 (0.95–1.61) | 0.115 | Random | 88.7 | 0.000 | |
Caucasian | 5 | 1.20 (1.11–1.31) | 0.000 | Fixed | 0.0 | 0.891 | |
OA site | |||||||
Knee OA | 9 | 1.18 (1.04–1.34) | 0.011 | Random | 67.1 | 0.002 | |
Hip OA | 4 | 1.31 (1.18–1.44) | 0.000 | Fixed | 39.9 | 0.172 | |